载脂蛋白E基因启动子多态性与年龄相关性黄斑变性的关系

Relationship between the Apolipoprotein E Promoter Polymorphisms and the Risk of Age-related Macular Degeneration

目的:探讨载脂蛋白E(APOE)基因启动子(-219G/T)多态性与年龄相关性黄斑变性(AMD)发病危险性的关系。方法:用聚合酶链反应-限制性片断长度多态性分析法对AMD组(50例)和对照组(95例)的APOE-219G/T基因型做出鉴定。结果:两组间不存在-219G/T基因型频率分布的差异(P>0.39)。结论:APOE基因-219G/T多态性与AMD发病危险性无关。

Objective： To study the relationship between apolipoprotein E（APOE） promoter（-219G/T）polymorphisms and the risk of age-related macular degeneration（AMD）. Methods： APOE-219G/T genetype in AMD group（50 cases） and control group（95 persons）was identified by polymerase chain reaction and restriction fragment length polymorphism genotyping technique. Results： No significant difference was found between two groups on the distribution of APOE -219G/T genotype. Conclusion： The APOE -219G/T polymorphisms do not contribute to AMD risk.