N-乙酰半胱氨酸治疗慢性阻塞性肺病急性发作期疗效观察

Treatment of AECOPD with N-acetylcysteine

目的观察应用N-乙酰半胱氨酸治疗慢性阻塞性肺病急性发作期(AECOPD)患者的疗效。方法将76例AECOPD随机分为治疗组和对照组各38例,患者均酌情使用茶碱缓释剂及抗生素治疗,治疗组在此基础上给予口服N-乙酰半胱氨酸颗粒剂治疗,每次200mg,每日三次,均于餐后服用,疗程14d。对照组不给予口服N-乙酰半胱氨酸颗粒剂治疗,观察治疗前后两组患者咳嗽、咳痰、气促症状等临床症状及肺功能变化情况。结果治疗组患者临床症状显著好转者(显效)22例,有效11例,总有效率86.84%;对照组显效11例,有效16例,总有效率71.05%;2组比较有显著性差异,(P<0.05)。治疗组FEV1改善较对照组明显(P<0.05)。结论N-乙酰半胱氨酸用于AECOPD患者可以减轻气流阻塞,防止氧化应激,改善患者的呼吸功能,且使用安全。

Object To investigate the effect of AECOPD with N - acetylcysteine. Methods 76 patients were divided into two groups randomly, each group contained 38 patients. All patients were treated with Slow - release theophyline or antibiotic while patients need. The treatment groups were given N - acetylcysteine granulated powder, three times daily. The course of treatment was 14 days. Control group patients were not given N- acetylcysteine granulated powder. Observe the change of cough, expectoration, dyspneic symptom and FEV1 in patients. Results In treatment group have 22 case clinic symptom improvement significantly, 11 case clinic symptom improvement. Total effective rate is 86.84%. In control group have 11 case clinic symptom improvement significantly, 16 case clinic symptom improvement. Total effective rate is 71.05%. Two groups were difference significantly in statistics （P 〈0.05 ）. IN treatment group FEV1 were more improvement than in control group （P 〈 0.05 ）. Conclusion N - acetylcysteine can alleviate airway obstruction, avoid oxidative stress, improve pulmonary function and safe in AECOPD patients.