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他汀类药物与肺纤维化 被引量:4

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摘要 他汀类药物通过减少FPP和GGPP从而抑制Rho和Ras的修饰,阻断细胞内某些生长因子的信号传导途径,而不依赖于抑制HMG-CoA还原酶而发挥作用,从而表现出多效性。他汀类药物可从血管通透性、血管新生、血管的粘附作用以及成纤维细胞的增殖和胶原的产生诸多方面对肺纤维化发挥治疗作用。
出处 《西部医学》 2007年第2期295-297,共3页 Medical Journal of West China
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