埃索美拉唑治疗幽门螺旋杆菌相关性消化性溃疡

Treating Hp-related digestive ulcer with esomeprazole

目的:观察埃索美拉唑治疗消化性溃疡的临床疗效及对幽门螺杆菌(HP)感染的清除率。方法:98例消化性溃疡患者,其中埃索美拉唑组48例,给埃索美拉唑20mg,Po,bid,共1周,安慰剂3周;奥美拉唑组50例,给奥美拉唑20mg,Po,bid,共3周。疗程结束时,复查胃镜观察溃疡的愈合情况。结果:埃索美拉唑组胃溃疡腹痛消失时间为(2.8±1.2)d,十二指肠溃疡为(1.8±0.5)d;奥美拉唑组分别为(3.8±1.9)d和(2.6±1.0)d,经统计学处理有显著性差异(P<0.01)。溃疡的愈合率和HP清除率,与奥美拉唑组70%和60%相比(P<0.01),埃索美拉唑组分别为95.8%和91.7%。结论:埃索美拉唑能明显缓解消化性溃疡症状,止痛效果快,对溃疡有较高的愈合率及HP清除率。

Objective： To observe the efficacy in treating digestive ulcer and cleaning rate of helicobacter（HP） by Esom eprazole.Methods： we selected 98 cases of digestive ulcer and classified them into 2 groups, namely, esomeprazole （N=48） group （Group Ⅰ） and omeprazole group（N=50, Group Ⅱ）. We administrated esomeprazole （20mg, Po, bid, 1 week） and placebo （3 weeks） to the patients in Group Ⅰ. And in Group Ⅱ we treat them with omeprazole（20mg, Po, bid, 3 weeks）. After treatment, we reexamine the situation of recovery with gastroscope.Results： In Group Ⅰ, the time of bellyache disappearing in gastric ulcer was 2.8±1.2 days and in duodenal ulcer 1.8±0.5 days. In Group Ⅱ, these figures were 3.8±1.9 days and 2.6±1.0 days respectively. Statistically, there were significant difference between 2 groups （p〈0.01）. The recovery rate and cleaning rate of Hp were 95.8% and 91.7% respectively in Group Ⅰ and 70% and 60% in Group Ⅱ, There were sigriificant difference between 2 groups （p〈0.01）. Conclusion： Esomeprazole can alleviate the symptoms of digestive ulcer with a rapid pain-killing effect. It produces a higher Hp cleaning rate.