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酶法7-ACA结晶过程研究

Study on Crystallization Process of 7-ACA Prepared by Enzymic Method
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摘要 头孢菌素C钠盐(CPCNa)在D-氨基酸氧化酶(DAO)和戊二酰-7-ACA酰化酶(GAC)双酶催化反应下得到7-氨基头孢烷酸(7-ACA)。在7-ACA结晶时,通过对比添加0.1‰阳离子型高聚物聚四胺辅助结晶和普通结晶方法,发现聚四胺可有效使晶体聚结成球状,大大提高了结晶后过滤速度、7-ACA含量和质量以及7-ACA成品稳定性。同时,对聚四胺的加入量进行了优化。 7-Aminocephalosporanic acid (7-ACA) was prepared by using D-amino acid oxidase and Glutaryl-7-ACA acylase to catalyse cephalosporanic C sodium splitting. When we studied on the crystallization process of 7-ACA, we compared the general crystal method with the method of adding 0.1‰ cationic polyquaternary amine in crystallization process. The result displayed that polyquaternary amine could gather the cystal of 7-ACA together to sephericity, and the filter speed ,content ,quality and stability of 7-ACA was improved. At the same time, the quantity of polyquaternary amine added was optimized.
出处 《河北化工》 2007年第3期37-38,共2页 Hebei Chemical Industry
关键词 7-氨基头孢烷酸 结晶 聚四胺 7-aminocephalosporanic acid: crystallization polyquaternary amine
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参考文献5

  • 1A Reichert, W. Riethorst, F. Knauseder, et al. Esterase Free Enzymes[P]. WO:9 913 058,1999,3.
  • 2王水,王静康,龚俊波.7-氨基头孢烷酸结晶过程聚结现象与晶体表面性质[J].天津大学学报,2006,39(5):585-591. 被引量:2
  • 3许岗,朱敏,莫章华等.7-氨基头孢烷酸的结晶方法[P].CN:1511 956,2004,7.
  • 4金正优,申相圭,崔相镕等.7-氨基头孢烷酸的结晶方法[P].CN:1 697 837,2005,11.
  • 5P.纳德尼克,H.瓦格纳.7-氨基头孢烷酸(7-ACA)的改进沉淀法[P].CN:1 158 289,2004,7.

二级参考文献9

  • 1Huber F M, Chauvette P R, Jackson B G. Cephalos porinsand Penicillins : Chemistry and Biology [ M ]. New York : Academic Press, 1972.
  • 2Mandelbrot B B. Fractal: Form, Chance and Dimension[ M ]. New York: Freeman, 1977.
  • 3Pugh R J, Bergstrom L. Surface and colloid chemistry in advanced ceramics processing [ J ]. Surfactant Science Series,1994,51:245- 277.
  • 4Meakin P. Formation of fractal dusters and networks by irreversible diffusion-limited aggregation [ J]. Phy Rev Lett,1983,51 : 1119-1122.
  • 5Weitz D A, Oliveria M. Fractal structures formed by kinetic aggregation of aqueous gold colloids [ J ]. Phys Rev Lett,1984, 52:1433-1436.
  • 6Shih W Y, Aksay I A, Kikuchi R. Reversible-growth model: Cluster-cluster aggregation with finite binding energies[J]. Phys Rev A, 1987,36:5015-5020.
  • 7Yang Qingfeng, Ding Jie, Shen Ziqiu. Investigation on fouling behaviors of low-energy surface and fouling fractal characteristics [ J ]. Chemical Engineering Science, 2000, 55 :797-805.
  • 8Bulycheva M S, Nys P S, Savitskaya E M. Physicochemical properties of 7-amino acetoxy cephalosporanic acid [ J ]. Antibiotiki, 1977,22 (12) : 1073-1077.
  • 9艾德生,李庆丰,戴遐明.超细白云石矿粉润湿接触角的测定[J].岩矿测试,2001,20(2):97-99. 被引量:9

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