摘要
目的:对苦参碱磁性壳聚糖微球制备工艺进行筛选。方法:分别用化学共沉淀法制备磁流体和离子凝聚法制备苦参碱磁性壳聚糖微球,并采用可视化优化方法对磁流体和微球制备工艺条件进行分析处理,预测出优化的工艺条件。结果:采用预测条件制备的磁流体的平均粒径为152.2 nm,苦参碱磁性微球的平均粒径为682.4nm,粒径分布均匀。结论:可视化优化方法能有效对苦参碱磁性壳聚糖微球的制备工艺进行筛选。
Objective： To study the techmigue of preparation and optimization of magnetic chitosan microspheres. Methods： Magnetic fluid was produced by co-precipitation method and magnetic chitosan microspberes were produced using a convenient method of ionic gelation. A global optimization algorithm was used to optimize the parameters. Results： The formulated magenetic fluid and microspheres were characterized size and the size distribution. The average particle size of magnetic fluid and matrine-loaded chitosan magnetic microspberes were found to be 152. 2nm and 682. 4nm. Conclusion： Global optimization algorithm is an efficient method to optimize the parameters.
出处
《中药材》
CAS
CSCD
北大核心
2007年第1期82-85,共4页
Journal of Chinese Medicinal Materials
关键词
苦参碱
壳聚糖
磁性微球
可视化优化方法
Matrine
Chitosan
Magnetic microspheres
Global optimization algorithm
