预防颈动脉成形术后再狭窄的实验研究进展

Experimental study on prevention of carotid artery restenosis after angioplasty

颅外颈动脉硬化闭塞性疾病是多种缺血性脑血管病的重要危险因素，目前临床上应用的颈动脉内膜切除术（CEA）、血管成形支架置入术（CAS）等方法近期虽可获得理想的血液再灌注，但各种血管成形术后3～6个月内高达25％～50％的再狭窄率，严重影响了临床效果，且没有有效的防治方法。因此，近年来有关抑制颈动脉成形术后血管再狭窄的基因、药物和放射等方面的试验研究日渐增多。

Extracranial carotid arterial stenostic disease is one of the important dangerous factors in transient ischemic attacks （TIA） and ischemic stroke. Although carotid endarterectomy （CEA） and carotid artery andioplasty and stent placement （ CAS ） can obtain the ideal short-term reperfusion, the effect of each kind of angioplasty has been seriously affected by a high incidence of restenosis, which has been reported to be as high as 25% - 50% within 3 - 6 months and has no effective preventing and controlling method. Therefore, gene, medicine and radiotherapy experimental studies on inhibition of vascular restenosis after carotid artery angioplasty increase day after day.