TAI联合放射治疗晚期直肠癌的临床研究

Therapeutic results of TAI regimen chemotherapy combined with radiation therapy in the treatment of advanced rectal carcinoma

目的探讨经直肠下动脉介入化疗(TAI)方案联合放射治疗晚期直肠癌的疗效及毒副反应。方法回顾分析68例晚期直肠癌的随访资料,根据治疗方法不同分为TAI联合放射治疗组和单纯放疗组,分析肿瘤的缓解率、患者的生存率及毒副反应。结果TAI方案联合放疗组在肿瘤的消失、缩小方面优于单纯放疗组,两者差异有显著意义(P<0.05)。TAI组联合放疗组1、2、3年的生存率明显高于单纯放疗组,两者有显著性差异(P<0.05);5年生存率相近,但TAI组联合放疗组较单纯放疗组消化道I^II度毒副反应发生率明显增加,差异有显著性意义(P<0.05)。结论TAI方案联合放射治疗能提高局控率,降低复发率,减少局部淋巴和远处转移率,有效提高长期生存率,且并发症发生率较低,是一种简单、安全、较理想的中晚期直肠癌的治疗方案,有临床推广价值。

Objective： To explore the curative effect and side effects of TAI regimen combined with radiation therapy in the treatment of advanced rectal cancer . Methods： Data of sixty eight rectal cancer patients were analyzed respectively. The patients were divided into two groups based on different treatment. Group A received TAI regimen chemotherapy combined with radiation therapy, while group B received radiation therapy alone , analyze the tumor remission rate,survival rate and side effects. Results： TAI regimen chemotherapy combined with radiation therapy was more effective than radiation therapy. 1,2,3 year survival rates of group A were significantly higher than those of group B. However I to Ⅱ grade gastrointestinal tract toxicity of group A was more than group B. Conclusion： The synthetic therapy of TAI regimen chemotherapy combined with radiation therapy can improve local control rate, reduce recrudescence rate, local lymph node metastasis rate and metastasis rate. Also, it could improve long- term survival rate, and its adverse event rate is lower, is a simple, effective therapy for advanced rectal cancer.