无水酒精局部注射治疗血管瘤后VEGF的变化及意义

Serum VEGF level of the patients with hemangioma before and after alcohol injection

目的寻找一种客观的指标来反映血管瘤患者经无水酒精局部注射后的临床效果,探讨VEGF与血管瘤的发病机制的关系。方法用免疫酶标技术分别检测10例正常人,10例海绵状血管瘤患者,及上述10例血管瘤患者经无水酒精局部注射一周后及一个月后外周血血清中VEGF的浓度。结果10例血管瘤患者血清中VEGF浓度明显高于正常人组(P<0.01);10例血管瘤患者经无水酒精局部注射一周后血清中VEGF浓度与血管瘤患者组无明显区别(P>0.01);10例血管瘤患者经无水酒精局部注射一个月后外周血血清中VEGF浓度与正常人组无明显差别(P>0.01)。结论免疫酶标技术可以准确测量血管瘤患者及经无水酒精局部注射后外周血血清中VEGF的浓度;VEGF可以作为一种客观依据来反映局部注射无水酒精的临床治疗效果及预后;血管瘤患者局部注射无水酒精方法临床效果确切。为以后临床上各种方法的疗效判断提供依据。

Objective To look for an objective biomedical index to reflect the clinical effect of hemangioma Patients who had been injected with alcohol and to study the relationship between VEGF and hemangioma. Methods ELISA（ enzyme- linked immunosorbent assay）was used to determine serum VEGF concentrations of 10 healthy beings, 10 patients with hemangioma, who had been injected with alcohol for a week, a month. Results The serum VEGF concentrations of 10 patients with hemangioma were significantly higher than those of healthy beings, The serum VEGF concentrations of those who had been injected with alcohol for a week were significantly higher than those of healthy beings, the serum VEGF concentrations of those who had been injected with alcohol for a month was a little higher than those of healthy beings, but without statistic significance. Conclusion ELISA can easily and accurately determine the serum VEGF concentrations of patients with hemangioma who have been injected with alcohol. The determination of serum VEGF concentrations can provide guidance for clinical effects of patients with hemangioma who have been injected with alcohol. Injecting alcohol is an useful clinical method for patients with hemangioma. ELISA can provide an objective basis for selecting clinical treatment to hemangioma.