房水中白细胞介素-6浓度与糖尿病黄斑水肿的相关性研究

Study on correlation between level of interleukin-6 in aqueous humor and diabetic macular edema

目的本研究主要观察房水中白细胞介素-6（inter-leukin-6，IL-6）浓度与糖尿病黄斑水肿（diabetic macular edema，DME）严重程度的关系。方法对接受白内障超声乳化及人工晶状体植入术的非增生性糖尿病视网膜病变患者57例65眼行回顾性研究，术前获得房水样本，采用酶联免疫法检测房水中IL-6质量浓度，同时对可能影响DME的因素进行统计学分析。结果65眼房水中IL-6浓度为12．17-327．99 μg· L^-1（平均为62．44 μg· L^-1）。多因素Logistic回归分析发现，房水中IL-6浓度增高，糖尿病患者并发临床意义的黄斑水肿可能性增大。回归方程为Y=EXP（5．49—4．16×X6），P〈0．01。房水中IL-6浓度与DME严重程度显著相关（r=0．63，P〈0.01），并且随着房水中IL-6浓度增加。DME严重程度增加。结论房水中IL-6的浓度与DME的严重程度有关，并且随着IL-6浓度的增加。DME的严重程度也增加。[眼科新进展2007；27（3）：198-200]

Objective To observe the correlation between the level of interleukin-6（ IL-6 ） in the aqueous humor and the severity of diabetics macular edema （DME）. Methods This retrospective study ineluded 57 patients （ 65 eyes） with nonproliferative diabetic retinopathy who had cataract surgery, IL-6 in undiluted aqueous specimens collected before surgery were measured by enzyme-llnked immunosorbent assay, Several factors possible related to DME were analyzed. Results The level of IL-6 in the aqueous humor of 65 eyes was 12.17 -327.99 μg· L^-1 （mean 62.44 μg· L^-1 ）. Multivariate logistic regression analysis showed that,with the level of IL-6 in the aqueous humor increased, the possibility of complicating clinical significant macttlar, edema in diabetic patients increased, and other system factors including age, course of diabetes,glycosylated hemoglobin,hypertention,treatment of insulin had no effect on DME. The regression equation was Y=EXP（5.49- 4.16 ×X6）, P〈0.01.The level of IL-6 in the aqueous humor was significantlyt correlated with the severity of DME（ r = 0.63,P 〈 0.01）,with the level of IL-6 in the aqueous humor increased,the severity of DME increased. Conclusion The level of IL-6 in the aqueous humor is positive correlated with the severity of DME. With the level of IL-6 in the aqueous humor increases, the severity of DME also increases. [Rec Adv Ophthalmol 2007;27（3） ：198-200]