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骨保护素及其配体在口腔领域的研究进展 被引量：1

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摘要 骨保护素及其配体在骨代谢中起着重要的作用,该文主要阐述骨保护素(OPG)及其配体以及骨保护素配体的受体(RANK),讨论三者在牙槽骨骨改建的分子机制。
作者 郑茜聪 刘丽
机构地区 浙江大学附属口腔医院修复科
出处 《口腔医学》 CAS 2007年第2期104-106,共3页 Stomatology
基金 浙江省自然科学基金资助项目(Y204061)
关键词 骨保护素 牙槽骨改建 破骨细胞 骨吸收
分类号 R341.8 [医药卫生—基础医学]
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参考文献23

  • 1Simonet WS,Lacey DL,Dunstan CR,et al.Osteoprotegerin:a novel secreted protein in the regulation of bone density[J].Cell,1997,89(2):309-319.
  • 2Tan KB,Harrop J,Reddy M,et al.Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF recepter superfamily genes and their constructive and inducible expression in hematopoietic and non-hematepoictic cells.Gene,1997,204(1-2):35-46.
  • 3Tsuda E,Goto M,Mochizuki SI,et al.Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis[J].Biochemical and Biophysical Research Commnunications,1997,234(1):137-142.
  • 4Bueay N,Sarosi I,Dunstan CR,et al.Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.Genes Dev,1998,12(9):1260-1268.
  • 5Fuller K,Wong B,Fox S,et al.TRANCE is necessary and sufficient for osteoblast-mediated aetivation of bone resorption in osteoclasts[J].J Exp Med,1998,188(5):997-1001.
  • 6Nakagawa N,Kinosaki M,Yarnaguchi K,et al.RANK is the essential signaling recepytor for Osteoclast Differentiation Factor in osteoclastogenesis[J].Biochem BiophysRes Commun,1998,253(2):395-400.
  • 7Hsu H,Lacey DL,Dunstan CR,et al.Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand[J].Proc Natl Acad Sci USA,1999,96(7):3540-3545.
  • 8Arai F,Miyamoto T,Ohneda O,et al.Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-fms and receptor activator of nuclear factor κB(RANK) receptors[J].J Exp Med,1999,190(12):1741-1754.
  • 9Yamane T,Kunisada T,Yamazaki H,et al.Sequential requirements for SCL/tal-1,GATA-2,macrophage colony-stimulating factor,and osteoclast differentiation factor/osteoprotegerin ligand in osteoclast development[J].Exp Hematol,2000,28(7):833-840.
  • 10Lacey DL,Tan HL,Lu J,et al.Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo[J].Am J Pathol,2000,157(2):435-448.

二级参考文献25

  • 1[1]Hofbauer LC, Khosla S, Lacey DL, et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res, 2000, 15: 2-12.
  • 2[2]Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin:a novel secreted protein involved in the regulation of bone density. Cell, 1997,89: 309-319.
  • 3[3]Tsuda E, Goto M, Mochizuki S, et al. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun, 1997,234:137-142.
  • 4[4]Hakeda Y, Kobayashi Y, Yamaguchi, et al. Osteoclastogenesis inhibitory factor(OCIF) directly inhibits bone-resorbing activity of isolated mature osteoclasts. Biochem Biophys Res Commun,1998,251 : 796-801.
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  • 7[7]Verna C, Zaffe D, Siciliani G. Histomorphometric study of bone reactions during orthodontic tooth movement in rats.Bone, 1999, 24: 371-379.
  • 8[8]Kabasawa M, Ejiri S, Hanada K, et al. Effect of age on physiologic and mechanically stressed rat alveolar bone: a cytologic and histochemical study. Int J Adult Orthod Orthognath Surg, 1996, 11: 313-327.
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共引文献23

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口腔医学
2007年 第2期

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