肺炎支原体DNA检测及其与慢性鼻窦炎的相关性研究

Investigation on the relationship between mycoplasms pneumoniae infection and the pathogenesis of chronic sinusis by determining DNA content of the organism

目的探讨肺炎支原体感染与慢性鼻窦炎的相关性。方法采用聚合酶链反应检测61例慢性鼻窦炎患者鼻腔-鼻窦黏膜的肺炎支原体感染情况,与31例健康对照者的检测结果进行比较,分析肺炎支原体感染与慢性鼻窦炎的病理相关性。结果慢性鼻窦炎组中检出肺炎支原体4例,对照组中检出1例,经χ2检验,两组检出率差异无显著性意义(P>0.05)。结论肺炎支原体可能是某些慢性鼻窦炎病例的致病微生物,但非慢性鼻窦炎的主要致病因素。

Objective To investigate the pathogenic association between infection of mycoplasms pneumoniae with the development of chronic sinusitis. Methods Polymarase chain reaction （PCR） technique was used to detect the DNA content of mycoplasms pneumoniae to evaluate the infection status of this kind of pathogen in nasosinous mucosa among 61 cases with chronic sinusitis, with 31 healthy persons as controls. Then, a comparative analysis was made to explore the association of such an infection with the pathogenesis of sinusitis. Results Four out of these case with chronic sinusitis were detected with infection of mycoplasms pneumoniae, while only one case was detected with such an infection among the controls, with no significant difference between them （P 〉0.05）. Conclusion Mycoplasms pneumoniae should be one of the pathogenic organisms for some cases with chronic sinusitis, while it may not be the predominant factor of pathogenesis.