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水痘-带状疱疹病毒性脑血管炎的临床表现以及影像学、病理学改变 被引量:3

Clinical Features,Neuroimage and Pathologic Changes in Varicella-Zoster Virus-Induced Vasculitis Presenting with Cerebral Infarction
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摘要 目的分析水痘-带状疱疹病毒(VZV)引起的脑动脉炎的临床特征、影像学和病理改变。方法对2例VZV脑动脉炎患者的临床表现、辅助检查、影像学和病理特征进行了总结。结果患者为急性起病,表现为脑卒中样发作,从病毒感染到脑梗死的发生间隔时间分别为5d和6个月,头颅MRI表现为半卵圆、双侧基底节区的多发性长T1、长T2信号,注射钆喷酸葡胺(Gd-DTPA)后无增强效应。数字减影血管造影术(DSA)检查发现在大脑中动脉、前动脉存在多处狭窄段。病理学检查发现,在脑组织血管周围有炎性细胞浸润,呈血管鞘样,脑内血管存在多处明显的纤维素样坏死。该病预后良好。结论VZV引起的脑动脉炎存在病毒前驱感染病史,具有较为特征的临床和影像学表现。 Objective To analyze the clinical features, neurolmage and pathologic changes in varicella-zoster virus-induced vasculitis presenting with cerebral infarction. Methods The clinical data including clinical manifestation, laboratory examination, neuroimage and pathologic changes of the two patients with varicella- zoster virus-induced vasculitis presenting with cerebral infarction were collected and analyzed. Results The patients presented acute ischemie-stroke episode attacks. The latent period between the viral infection and neurological complaints was 5 days and 6 months respectively, MRI image showed abnormal signals in the territory of the bilateral anterior and middle cerebral artery, indicated the presence of acute multi-focal infarction, and digital subtraction angiography (DSA) showed multiple scattered segments of irregularity and narrowing involving the small and medium-sized vessels. Neuropathologic study demonstrated fibrinoid necrosis and infiltration of inflammation cells around vessel wall. Conclusions Varicella-zoster virus-induced cerebral vasculitis has a prodrome of viral infection, and possesses characteristic clinical features.
出处 《中国神经免疫学和神经病学杂志》 CAS 2007年第2期105-108,共4页 Chinese Journal of Neuroimmunology and Neurology
关键词 水痘-带状疱疹 脑动脉炎 脑梗死 varicella zoster virus cerebral vasculitis cerebral infarction
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参考文献5

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同被引文献22

  • 1杨琴,杨军.17例带状疱疹性脑膜炎临床分析[J].现代医药卫生,2004,20(17):1705-1706. 被引量:2
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  • 3范团起,李卫红.更昔洛韦治疗带状疱疹疗效观察[J].中国实用神经疾病杂志,2006,9(3):57-58. 被引量:9
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  • 10吕亚萍,黄葵,马雪梅,黄可祥,兰庆茂,黄忠道,朱楠,黄菊.艾滋病合并弓形体虫脑炎的MRI表现[J].实用放射学杂志,2011,27(7):989-991. 被引量:12

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