神经精神性狼疮的研究进展

Advancement about Research of Neuropsychiatric Systemic Lupus Erythematosus

神经精神性狼疮(NPSLE)是系统性红斑狼疮(SLE)的严重并发症,其临床表现复杂多样,主要表现为头痛、癫痫、脑血管病、认知障碍、抑郁、焦虑。NPSLE可发生于SLE病程的任何阶段,其可能的发病机制是多方面的,包括自身抗体的产生、微血管病变以及炎性介质的参与。对于NPSLE诊断,国际上尚无统一的标准,必须综合运用免疫血清学检查、神经影像学检查及神经精神的评估。其治疗主要包括免疫抑制,对症治疗以及抗凝治疗。

Neuropsychiatric systemic lupus erythematosus （NPSLE） is a serious and well known complication of systemic lupus erythematesus and manifested by a wide variety of clinical manifestations including headache, seizures,cerebrovascular disease,cognitive dysfunction,depression and anxiety. NPSLE can occur any phase of SLE, whose pathomochanism maybe result from the participation of many factors including autoantibody production, microvasculopathy and pro-inflammatory cytokines. There is no unified diaoaesis for NPSLE, which must be evaluated by the general methods including immunosemlogical testing, neuroimaging and neuropsychological assessments. The management of NPSLE mainly includes immunosuppression, symptomatic treatment and anticoagulant therapy.