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白细胞介素-18与缺氧缺血性脑损伤的关系 被引量：2

The Relationship Between Interleukin-18 And Hypoxic-Ischemic Brain Damage
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摘要 白细胞介素-18(IL-18),最初被称为干扰素诱导因子(IGIF),它在结构上与IL-1同源,被半胱氨酸蛋白酶-1(caspase-1)催化成熟,是一种重要的前炎性细胞因子。在缺氧缺血性脑损伤(HIBD)后其表达明显增强,促进了HIBD后炎性反应的发生及损伤的发展。近年来,IL-18在HIBD中的作用被广泛关注。本文主要就IL-18与HIBD的关系作一综述。 Interleukin-18（IL-18） is a cytokine which was initially described as IFN-T inducing factor（IGW）. IL-18 having structural homology with IL-1 is an important proinflammatory cytokine and matured by catalysis of caspase-1. IL-18 has increased expression obviousely in HIBD and promote the occurrence and development of inflammatory reaction in HIBD. Nowdays, the effect of IL-8 in HIBD is attracting more attention. This article reviews the relationship between IL-18 and HIBD.
作者 邹礼乐 雷小平 刘广益
机构地区 四川省泸州医学院组织学与胚胎学教研室 四川省泸州医学院附属医院儿科
出处 《医学综述》 2007年第6期451-453,共3页 Medical Recapitulate
关键词 缺氧缺血 脑 白细胞介素-18 白细胞介素-1 半胱氨酸蛋白酶-1 Hypoxia and isehemia Brain Interleukin-18 Interleukin-1 Caspase-1
分类号 R743.31 [医药卫生—神经病学与精神病学]
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参考文献18

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同被引文献17

  • 1方勇,孙毅,唐成和.超小剂量肝素佐治新生儿缺氧缺血性脑病并全身炎症反应综合征76例[J].新乡医学院学报,2006,23(4):398-400. 被引量：20
  • 2张慧玲,许现军.丽珠赛乐联合抚触按摩治疗中重度新生儿缺氧缺血性脑病31例[J].新乡医学院学报,2007,24(3):261-262. 被引量：24
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医学综述
2007年 第6期

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