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DNA甲基化与非小细胞肺癌临床关系研究进展

Clinical Relationhip Progress Between DNA Methylation and NSCLC
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摘要 DNA甲基化与肿瘤临床关系是目前肿瘤分子生物学研究的热点。研究显示,DNA甲基化是非小细胞肺癌(NSCLC)诊断、分期及治疗预后特异性较强的标识物。NSCLC患者血清或呼吸道分泌物DNA甲基化检测标本易于获取,无需切取活体组织,检验技术实用方便,对NSCLC的临床及预后具重要意义。 Clinical relationship between DNA Methlation and tumor is the study hot in oncomolecularbiology at present. Many studies showed that DNA methylation is specific marker of NSCLC in its diagnosis, staging, treatment and prognosis. Samples used for DNA methylation detection from serum and respiratory secretion of patients with NSCLC can be had easily, and DNA methylation detection with utility and convenient needn＇t exciding living tissue, which has an important significance in the clinic and prognosis of NSCLC.
作者 乔华 李晓光 王萍 周小寒
机构地区 上海交通大学附属第一人民医院宝山分院介入科 苏州广慈肿瘤医院检验科 上海交通大学附属第一人民医院肿瘤科
出处 《医学综述》 2007年第5期344-345,共2页 Medical Recapitulate
关键词 癌 非小细胞肺 DNA甲基化 临床研究 肿瘤转移 预后 Cancer, NSCLC DNA Methylation Clinical Research Tumor metastasis prognosis Advance
分类号 R734.2 [医药卫生—肿瘤] R730.7 [医药卫生—肿瘤]
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参考文献15

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医学综述
2007年 第5期

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