摘要
FADD是Fas系统的一个信号连接蛋白,是死亡受体与胞浆成分之间联系的纽带,介导细胞凋亡。恶性转化的肿瘤细胞是因为生长失控导致的过度增殖,肿瘤细胞凋亡机制受到抑制而导致肿瘤细胞不能进行正常凋亡并且清除。FADD作为凋亡信号的连接蛋白,在恶性肿瘤的发生、发展过程中起着重要的作用,现就FADD与恶性肿瘤的关系进行综述。
FADD is a signal connectin in Fas-FasL apaptotic path, which is the vinculum between death receptor and endechylema elements mediating cell apaptosis. Tumour cells with malignant transformation is its over proliferation resulting from over growth out of control as wel as its abnormal apaptosis or clear out resulting from restrained mechanism of cell apaptosis. As a connectin in apaptosis signal, FADD plays an important role in genesis and development of malignant turnouts. This article is a review about relationship between FADD and malignant turnouts.
出处
《医学综述》
2007年第5期355-357,共3页
Medical Recapitulate
关键词
FAS相关死亡结构域蛋白
细胞凋亡
恶性肿瘤
Fas associated protein with death domain
Cells apaptosis
Malignant tumour
