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钠/钙和钠/氢交换蛋白与心肌缺血再灌注损伤 被引量：5

Exchanger of Na^+/Ca^(2+) and Na^+/H^+ and Myocardial Ischemical Reperfusion Injury
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摘要 Ca2+超载与缺血/再灌注损伤有密切关系,钠/钙交换蛋白和钠/氢交换蛋白是缺血/再灌注Ca2+超载过程中两个至关重要的因素。目前已有很多钠/钙交换蛋白(NCX)抑制剂和钠/氢交换蛋白(NHE)抑制剂用来防止Ca2+超载引起的缺血再灌注损伤。 Ca^2＋ overload is closely related to ischemia/reperfusion injury, Exchangers of Na^＋/Ca^2＋ and Na^＋/H^＋ are two critical factors during Ca^2＋ overload resulting from ischemia/reperfusion. At present,many inhibitors of Na^＋/Ca^2＋ exchanger and Na^＋/H^＋ exchanger were developed to prevent ischemia/reperfusion injury induced by Ca^2＋ overload.
作者 王雅锋 方秋娟
机构地区 福建医科大学基础医学院生理与病理生理学系
出处 《医学综述》 2007年第5期368-370,共3页 Medical Recapitulate
基金 福建省教委资金项目(K04051)
关键词 心肌缺血再灌注损伤 钙超载 Na^+/Ca^2+交换蛋白 质子 抑制剂 Ischemia/reperfusion injury Ca^2＋ overload Na^＋/Ca^2＋ exchanger Proton Inhibitor
分类号 R542.2 [医药卫生—心血管疾病] R540.47 [医药卫生—心血管疾病]
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参考文献20

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医学综述
2007年 第5期

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