先天性风疹综合征发病与监测研究现状及进展

The Study Status and Development of Congenital Rubella Syndrome in its Morbility and Monitoring

先天性风疹综合征(CRS)可表现为一过性、永久性畸形或晚发疾病,由于主要依靠实验室诊断国内对于CRS临床报道极少。CRS流行病学资料主要来源于发达国家,发展中国家虽然估算发病率高、疾病负担重却未得到重视。CRS的发生率取决于育龄期妇女对风疹的免疫状况及孕早期风疹病毒感染率,我国近年相关调查结果高于东南亚和西太区推算结果,证明风疹对孕早期妇女的威胁普遍存在。目前WHO和美国已制定出可靠的CRS监测定义,一些发展中国家也相继开展了CRS监测和调查,但这项工作在我国仍是空白。

Congenital Rubella Syndrome （CRS） can lead to temple, permanent or delayed deformity and impairment, whose clinical report is very scarce in out country because its diagnosis is mainly depended on laboratory diagnosis. The epidemiological data of CRS is mainly from developed countries. The burdon resulting from this disease is still not payed more attention although its mobidity is estimated high in developing country. The mobidity of CRS is depending on immune conditionn of woman in child-bearing period and viral infection ratio in early pregnancy. The recent investigation data in our country is higher than that in Southeast Asia and West Pacific area, which indicated that rubella is a universal danger to woman in early pregnancy. Now, WHO and America have worked out reliable mornitoring definition of CRS. The monitoring and investigation of CRS is being carried out in developing country one after another,but this work is still blank in our country.