β-受体阻滞剂对高血压伴阵发性房颤患者P波离散度及P波最长时限的影响

The Effects of β-blocker on the Maximum P Wave Duration(Pmax)and P Wave Dispersion(Pd) in Hypertension Patients with Paroxysmal Atrial Fibrillation

目的:探讨β-受体阻滞剂对高血压伴阵发性房颤患者P波最大时限(Pmax)及P波离散度(Pd)的影响。方法:高血压伴阵发性房颤患者60例被随机分为美托洛尔治疗组(A组,30例)和对照组(B组,30例),两组高血压降压治疗基本相同,都使用钙阻抗剂或ACEI类药。A组加用美托洛尔25-50 mg/d。在治疗前、治疗后6个月分别测量Pmax和P波最短时间(Pmin),计算出Pd(Pd=Pmax-Pmin)。结果:治疗前两组Pmax和Pd比较无显著差异(P>0.05);治疗6个月A组的Pmax、Pd显著降低,与B组相同时间比较差异有非常显著性(P<0.01);A组治疗前与治疗后6个月比较Pmax、Pd相差有显著性(P<0.01);而B组间相差不显著(P>0.05)。A组房颤发作次数明显减少,与B组比较差异有非常显著性(P<0.01)。结论:β-受体阻滞剂治疗高血压伴阵发性房颤患者可明显降低Pmax、Pd,减少房颤发作次数。

Objective： To investigate the effects of β-blocker on the maximum P wave duration （Pmax）and P wave dispersion（Pd） in hypertension patients with paroxysmal atrial fibrillation （PAF）. Methods： Sixty patients were randomly divided into metoprolol treatment group（group A, n= 30）and control group（group B, n= 30）. Basic treatment of hypertension insufficiency in two groups was comparable. The patients（group A） were treated by metoprolol 25 ~50 mg/d. Pmax and Pd were measured based on the 12-lead electrocardiogram at the beginning and a half year, the p wave dispersion（pd= max-min）. Results： Pmax and Pd were unsignificantly different before treatment; Pmax and Pd were significantly higher in group B than that in group A after 6 months treatment（P〈0. 01） ; Pmax and Pd were significantly higher after 6 months treatment than before treatment among group A（P〈（0. 01）; though Pmax and Pd were unsignificantly different among group B（P〉0.05）. paroxysmal atria fibrillation among A were significantly reduced, there were significant different between two groups （P〈0.01）. Conclusion： β-blocker significantly decreased Pmax and Pd,and recurence of paroxysmal atrial fibrillation in the patients.