阿霉素和吡喃阿霉素对乳腺癌患者心脏毒性的临床观察

Comparative Study of Cardiotoxicity of Anthracycline-containing of CAF and CTF Regimens in Patients with Breast Cancer

目的:探讨阿霉素和吡喃阿霉素对乳腺癌患者心脏毒性的临床观察。方法:对72例局部晚期乳腺癌患者随机分成2组,均是用环磷酰胺+阿霉素+5-氟脲嘧啶及环磷酰胺+吡喃阿霉素+5-氟脲嘧啶的联合化疗方案,通过检测患者心电图及心功能的变化,临床对照观察患者的心脏毒性反应。结果:吡喃阿霉素组较少出现心电图异常,4例心电图呈现一过性改变,较快2周恢复正常。阿霉素组,6例心电图改变,有4例在2周内恢复正常,1例有所减轻,但1例在1月后无改善,经超声心动图检测为充血性心力衰竭。结论:大多数患者能够较好地耐受阿霉素和吡喃阿霉素的化疗,吡喃阿霉素比阿霉素稍好,但经统计无显著性意义(P>0.05)。

Objective： To evaluate and compare the cardiotoxicity of THP regimens or ADM regimens in patients with breast cancer. Methods.76 patients with local advanced breast cancer were randomized into THP regimens （group CTF）or ADM regimens（group CAF）were observed for the cardiotoxity according to the change of electrocardiogram and echocardiography. Patients in both groups were well-matched with baseline disease characteristics（P〉0.05 ）. Results： In CTF group, there were 4 patients had transient electrocardiogram change and quickly recovered in 2 weeks. Six patients with abnormal electrocardiogram in the CAF group were detected, and among them 4 patients recovered in 2 weeks,a patient＇s symptom relieved partially and a patient was diagnosed as congestive heart failure two weeks later by echocardiography. Conclusion： The most patients have similar tolerance in two groups, P〉0.05. It looks that the CTF group are litter better than CAF group, but there was no statistically significant （P〉0.05）.