摘要
目的探讨挥发性有机物(VOC)诱发慢性荨麻疹的发病机制。方法以36只Wistar大鼠为研究对象,采用大气采样机采取混有VOC的空气样本,作用于大鼠长期接触组(VOCL组),3个月后再取尘螨、蟑螂、蚕丝变应原液注射于大鼠,观察皮肤及胸腺组织改变。并与双蒸水组、短期接触组(VOCS组)对照。结果VOCL组真皮浅层水肿,可见炎性细胞浸润,同时可见少数嗜酸性粒细胞,其胸腺组织CD4,CD8阳性表达细胞减少,阳性表达细胞的百分比降低,CD8的百分比较CD4的百分比高;双蒸水组、VOCS组炎性细胞较少;VOCS组有少许炎性细胞浸润,CD4,CD8阳性表达细胞增多,阳性细胞的百分比增高。结论VOC低水平长时间作用可导致机体的超敏反应,使变应原诱发慢性荨麻疹发生成为可能,同时对人体的免疫功能有抑制作用。
Objective To study the pathogenesis of chronic urticaria induced by Volatile Organic Compounds （VOC）. Methods 36 Wistar rats were divided into three groups ： The VOCL group, the positive control group , and the negative control group. The indoors air with VOC was collected by Atmosphere sampling-machine, then injected rat with allergents . and the skin and thymus tissue were observed. Results There were more cosinophilic granulocytes in the VOCL group than the control group, the infiltration of CD4 ,CD8 is less in the VOCL group than the control group. Conclusion The chronic urticaria might be evoked by the super-sensitive reaction induced by VOC. Besides. The VOC might inhibit the immune function.
出处
《公共卫生与预防医学》
2007年第1期24-25,28,112,共4页
Journal of Public Health and Preventive Medicine
关键词
挥发性有机物
荨麻疹
发病机制
Indoors air pollution
Volatile Organic Compounds
Chronie urticaria
Pathogenesis
