穴状型和Keggin型聚氧钨酸盐结构特征和抗HIV-1、抗癌活性

Characterization of Anti-human Immunodeficiency Virus and Inorganic Cryptate and Keggin-type Polyoxotungstate Anions,and their Anti-HIV,Anticancer Activities

目的综述无机穴状化合物(NH4)18[NaSb9W21O86]18-,和Keggin型聚氧钨酸盐作为抗人类免疫缺陷病毒-1(HIV-1)和抗癌药物的研究进展。方法根据构效关系对HPA-23和Keggin型聚氧钨酸盐进行体内体外研究。结果标题化合物穿透细胞膜进入细胞中,对HIV-1反转录酶或人体肿瘤有抑制活性。结论:直接揭示其可做为抗癌抗病毒药物。

Objective：To summarize the development of the inorganic cryptate （NH4）18[NaSb9W21086] 18- （HPA-23） and Keggin-type polyoxotugstate as anti-HIV-1 and anticancer agents. Methods In vitro and vivo studies of HPA-23 and Keggin-type polyoxotungstate anions on structure - activity relationships. Results：The Title compounds mentioned above can penetrate membranes and get into cells and have inhibitory activities against HIV-1 reverse transcriptase or human cancer. Conclusion：They can be developed into drugs as inhibitory agent against virus and cancer..