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附睾蛋白酶抑制剂Eppin的研究进展 被引量:5

Advances in the Studies of Epididymal Protease Inhibitor——Eppin
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摘要 附睾蛋白酶抑制剂Eppin是一种睾丸和附睾特异性分泌的蛋白质,精液中含量极为丰富,精子表面大量存在,用重组Eppin免疫的猴子出现不育,Eppin有望成为人类有效的可逆性的免疫避孕疫苗。现就Eppin基因及其蛋白质结构功能特点,Eppin引起免疫性不育的分子机制以及Eppin调控PSA水解精囊蛋白Semenogelin的研究进展进行了综述。 The epididymal protease inhibitor(Eppin) abounds in human semen and on the surface of human spermatozoa, specifically produced by the testis and epididymis. Recombinant Eppin has effected infertility in the immunized monkey and promises to be an effective vaccine for human immunocontraception. This article reviews the advances in the studies of Eppin gene and protein construction and its molecular mechanism of causing immunologic infertility and regulating PSA hydrolysis of Semenogelin. Natl J Androl,2007, 13(2) :168-170
作者 王增军 张炜
出处 《中华男科学杂志》 CAS CSCD 2007年第2期168-170,共3页 National Journal of Andrology
关键词 附睾蚤白酶抑制剂 精子 免疫疫苗 epididymal protease inhibitor spermatozoa immunocontraception
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参考文献14

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  • 3Wang Z, Widgren EE, Sivashanmugam P, et al. Association of eppin with semenogelin on human spermatozoa [ J ]. Biol Reprod,2005, 72 ( 5 ) : 1064-1070.
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  • 6Sivashanmugam P, Hall SH, Hamil KG, et al. Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2[J]. Gene, 2003. 312(2) :125-134.
  • 7王增军,吴宏飞,钱立新,乔迪,邵剑锋,张炜,眭元庚,徐正铨.人类精子表面附睾蛋白激酶抑制剂Eppin和精囊凝固蛋白Semenogelin的相互作用研究[J].中华男科学杂志,2006,12(5):428-431. 被引量:13
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二级参考文献27

  • 1Richardson RT, Sivashanmugam P, Hall SH, et al. Cloning and sequencing of human Eppin: A novel family of protease inhibitors expressed in the epididymis and testis[J]. Gene, 2001, 270(1-2):93-102.
  • 2Sivashanmugam P, Hall SH, Hamil KG, et al. Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2[J]. Gene, 2003, 312:125-134.
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  • 6Yenugu S, Richardson RT, Sivashanmugam P, et al. Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a when acidic protein motif[J]. Biol Reprod, 2004, 71(5):1484-1490.
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