摘要
附睾蛋白酶抑制剂Eppin是一种睾丸和附睾特异性分泌的蛋白质,精液中含量极为丰富,精子表面大量存在,用重组Eppin免疫的猴子出现不育,Eppin有望成为人类有效的可逆性的免疫避孕疫苗。现就Eppin基因及其蛋白质结构功能特点,Eppin引起免疫性不育的分子机制以及Eppin调控PSA水解精囊蛋白Semenogelin的研究进展进行了综述。
The epididymal protease inhibitor(Eppin) abounds in human semen and on the surface of human spermatozoa, specifically produced by the testis and epididymis. Recombinant Eppin has effected infertility in the immunized monkey and promises to be an effective vaccine for human immunocontraception. This article reviews the advances in the studies of Eppin gene and protein construction and its molecular mechanism of causing immunologic infertility and regulating PSA hydrolysis of Semenogelin. Natl J Androl,2007, 13(2) :168-170
出处
《中华男科学杂志》
CAS
CSCD
2007年第2期168-170,共3页
National Journal of Andrology
关键词
附睾蚤白酶抑制剂
精子
免疫疫苗
epididymal protease inhibitor
spermatozoa
immunocontraception