2型糖尿病合并代谢综合征与早期糖尿病肾病的相关性

Relationship between metabolic syndrome and early-stage diabetic nephropathy in type 2 diabetes mellitus

目的:探讨2型糖尿病(T2DM)合并代谢综合征(metabolic syndrome,MS)与早期糖尿病肾病(diabetic nephropathy,DN)发生的相关性。方法:采用回顾分析法,对南京医科大学第一附属医院2005年11月～2006年5月病房及门诊收治的478例T2DM患者资料进行统计。结果:研究中有64.2%的T2DM患者同时存在MS,伴有MS的患者出现早期DN的比例(36.2%)显著高于不伴有MS的患者(22.8%)(χ2=9.07;P<0.01);而在T2DM伴有MS的患者中,随着MS的组分增加,早期DN的发生率递增,差异有显著性(χ2=15.35;P<0.01);多因素Logistic回归分析显示,收缩压(SBP)、血清甘油三酯(TG)、糖化血红蛋白(HbA1C)、脂蛋白[LP(a)]均为早期DN发生的高危因素(P<0.05或P<0.01)。结论:MS与早期DN的发生密切相关,SBP、TG和HbA1C是早期DN的独立危险因素。

Objective：To study the relationship between metabolic syndrome （MS） and early-stage diabetic nephropathy （DN） in type 2 diabetes mellitus （T2DM）. Methods：478 cases of T2DM were screened for early-stage DN, and some correlated risk factors were analyzed. Results：Patients with MS （64.2%） had a higher prevalence＇of early-stage DN （36.2% vs. 22.8%, P 〈 0.01 ）. The proportion of early-stage DN was associated with MS features （16.67%, 26.74%, 36.43%, 45.68%, respectively,P 〈 0.01）. Triglycerides（TG）, systolic blood pressure （SBP）, glycosylated hemoglobin（HbA1C） and lipoprotein LP（a） were all independent risk factors of early-stage DN （P 〈 0.05 or P 〈 0.01 ）. Conclusion ： MS is significantly associated with early stage DN in patients with T2DM.