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白血病染色体研究:新发现与新进展 被引量：3

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摘要 白血病是获得性造血干细胞突变所致的克隆性疾病。染色体分析可以揭示作为恶性克隆标记的遗传学改变，因而受到重视，近年来，随着观察的深入和技术的进步，白血病的染色体研究又取得了重要进展。显带核型分析已成为白血病诊断的常规手段之一。分子一细胞遗传学新技术-荧光原位杂交（PISH）正作为前者的重要补充而得到广泛应用。现将白血病染色体研究的新发现和检测技术的新进展介绍如下。
作者 薛永权
机构地区 苏州大学附属第一医院 江苏省血液病研究所
出处 《中华医学杂志》 CAS CSCD 北大核心 2007年第8期508-511,共4页 National Medical Journal of China
关键词 白血病诊断 染色体分析 克隆性疾病 荧光原位杂交 遗传学改变 细胞遗传学 细胞突变
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献17

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  • 2Sinclair PB, Nacheva EP, Leversha M, et al. Large deletions at the t (9;22) breakpoint are common and may identify a poorprognosis subgroup of patients with chronic myeloid leukemia.Blood,2000, 95: 738-743.
  • 3吴炜,薛永权,吴亚芳,潘金兰,沈娟.Ph染色体阳性慢性粒细胞白血病衍生9号染色体缺失的FISH研究[J].中华血液学杂志,2006,27(3):183-186. 被引量：12
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二级参考文献8

  • 1Sinclair PB,Nacheva EP,Laversha M,et al.Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukaemia.Blood,2000,95:738-743.
  • 2Cohen N,Rozenfeld-Granot G,Hardan I,et al.Subgroup of patients with Philadelphia-positive chronic myelogenous leukemia characterized by a deletion of 9q proximal to ABL gene:expression profiling,resistance to interferon therapy,and poor prognosis.Cancer Genet Cytogenet ,2001,128:114-119.
  • 3Huntly B J,Reid A,Bench A,et al.Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic factor in chronic myeloid leukaemia.Blood,2001,98:1732-1738.
  • 4Kolomietz E,Al-Maghrabi J,Brennan S,et al.Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis.Blood,2001,97:3581-3588.
  • 5Huntly B J,Bench A,Delabesse E,et al.Derivative chromosome 9deletions in chronic myeloid leukemia:poor prognosis is not associated with loss of ABL-BCR expression,elevated BCR-ABL levels or karyotypic instability.Blood,2002,99:4547-4553.
  • 6Huntly B J,Guilhot F,Reid AG,et al.Imatinib improves but may not fully reverse the poor prognosis of CML patients with derivative chromosome 9 deletions.Blood,2003,102:2205-2212.
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  • 8Lundan T,Volin L,Ruutu T,et al.Allogeneic stem cell transplantation reverses the poor prognosis of CML patients with deletions in derivative chromosome 9.Leukemia,2005,19:138-140.

共引文献11

同被引文献13

引证文献3

二级引证文献4

中华医学杂志
2007年 第8期

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