MTHFR基因多态性与冠心病关系的Meta分析

Relationship between MTHFR Gene Polymorphism and Coronary Heart Disease in Chinese Population: a Meta Analysis

目的评价中国人群中亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与冠心病的相关性。方法通过文献检索收集MTHFR基因C677T多态性与冠心病关系的全文文献,剔除不符合要求的文献,在全面文献回顾的基础上对各研究OR值进行Meta分析。结果共有16篇符合条件的文献纳入分析,Meta分析结果表明,以野生型CC基因别为参照,携带T等位基因的个体发生冠心病的危险性的0R值为1.45,95%可信区间为(1.12,1.89),P<0.01。结论中国人群中T等位基因携带者易于发生冠心病。

Objective To study the relationship between methylcnetetrahydrofolate reductase （MTHFR） gcne polymorphism and eerenary heart disease in Chinese population by Meta analysis. Methods Through literature retrieval full texts with same topic and similar method were reviewed. A random effect model was applied to extract data and calculate OR value. Results 16 articles were eligible according to the criteria. Random effect OR of 1. 45 （95%CI： 1.12-1.89） for CT and Tr combined versus CC genotypo was found. Conclusions Meta analysis results suggest that MTHFR T allele carriers have an increased risk of suffering from coronary heart disease in Chinese population.