长时间低强度游泳运动对大鼠心血管系统CGRP mRNA表达的影响

THE EFFECT OF SWIMMING TRAINING ON THE EXPRESSION OF CARDIOVASCULAR CGRPmRNA IN RATS

目的:探讨长时间低强度游泳运动对心血管系统CGRPmRNA表达的影响。方法:雄性SD大鼠随机分为三组(n=8):安静对照组(CR)、运动力竭组(ER)和运动训练组(TR)。RT-PCR测定心尖肌组织和主动脉弓部血管CGRP mRNA的表达水平。结果:①一次急性有氧力竭游泳运动对大鼠心脏和主动脉CGRPmRNA表达无显著影响。②长时间进行低强度有氧游泳训练能引起心脏CGRPmRNA表达显著上调。结论:长期低强度的有氧运动训练后心脏在分子水平上有良好适应;而长时期进行低强度有氧游泳训练对主动脉CGRPmRNA表达无显著影响。

Aim： Rats cardiovascular expression of CGRPmRNA surveyed after an eight-week swimming training, and molecular mechanism of exercise-induced adaptation were studied. Methods： 24 purebred male SD rats were divided randomly into three groups（ n = 8） ： control（CR）, exhaust（ER）, train（TR）. After swimming training left ventricular muscle and main artery arch were extracted, we inspected the expression of CGRPmRNA by RT-PCR. Results： ①Comparing with the control group, once exhausting exercise had no significant effect on cardiovascular expression of CGRPmRNA. ②Comparing with the control group, long-term aerobic swimming training upregulated significantly cardiac expression of CGRPmRNA. Conclution： Long-term aerobic training induced benign cardiac adaptation in molecular level. Long-term aerobic swimming training had no significant effect on vascular expression of CGRPmRNA.