清肺平痤汤治疗肺热型痤疮临床研究

Clinical Research of Clean Lung Conquer Acne Decoction in Treating Lung-Heat Type Acne

目的证实中药清肺平痤汤治疗肺热型痤疮的疗效和药效学机制,以及对血清睾酮的影响。方法将80例痤疮患者随机分为2组。治疗组(50例)和对照组(30例)分别口服清肺平痤汤、一清胶囊,8周为1个疗程,对比观察临床疗效;同时观察用药后对血清睾酮的影响。结果对于肺热型痤疮患者,治疗组与对照组面部皮损有效率经χ2检验,P<0.01。治疗组治疗前后血清睾酮水平比较,P<0.01。对照组治疗前后血清睾酮水平比较,P<0.01。治疗组与对照组用药后组间血清睾酮水平比较,P<0.01。结论清肺平痤汤能够改善痤疮皮损症状,显著降低患者血清睾酮水平。清肺平痤汤对痤疮患者治疗效果及降低痤疮患者血清睾酮水平显著优于对照组。

Objective To confirm clinical curative effect and pharmacodynamics mechanism of Clean Lung Conquer Acne Decoction in treating lung-heat type acne, as well as its effect on androgen （andrusol）. Methods 80 cases of acne were divided into two groups randomly. Treatment group （50 cases） took orally Clean Lung Conquer Acne Decoction, control group （30 cases） took orally Yiqing capsule, 8 weeks was a course of treatment. Clinical therapeutic effect and serum andrusol were observed. Results To lung-heat type acne patient, skin damage effective of treatment group compared with control group, P〈0.01, Serum andrusol level of treatment group before and afer treatment, P〈0.01. Serum andrusol level of control group before and afer treatment, P〈0.01. After treatment, serum andrusol level of treatment group compared with control group, P〈0.01. Conclusion Clean Lung Conqur Acne Decoction can treat acne （lung-heat type） skin damage symptom effectively and decrease serum andrusol level significantly, which is better than control group Yiqing capsule.