抗焦虑抑郁药物对更年期女性高血压患者的协助治疗

The Adjunctive Effect of the Anti-anxiety-depression Drugs on the Treatment of Essential Hypertension in Menopause Women

目的研究抗焦虑抑郁药物氟哌噻吨0.5mg+美利曲辛10mg(商品名为黛力新)对更年期女性的高血压患者协同降压的疗效。方法对更年期女性高血压患者80例随机分为实验组(常规降压+黛力新)和对照组(常规降压+安慰剂)各40例,进行SCL-90评分并随访8周,比较两组血压的下降幅度、降压显效率、降压药物的数量以及治疗前后SCL-90评分的差异。结果(1)实验组在治疗2周后至结束时,血压的下降幅度[实验组:(130.6±13.5)/(80.7±10.3)mm Hg比对照组:(150.0±14.5)/(94.5±12.6)mm Hg,P<0.01]和降压显效率(86.8% vs 59.4%,P<0.01)较对照组明显提高。(2)治疗第5周后,对照组联合使用的高血压药物的数量明显较实验组明显增多(3.5±0.6vs1.8±0.6,P<0.01)。(3)实验组治疗后的SCL-90的焦虑、抑郁、躯体化症状因子评分较治疗前明显下降,对照组有轻度下降但仍明显高于常模。结论抗焦虑抑郁药物(黛力新)协同治疗更年期女性高血压患者的疗效显著,可以明显提高降压的有效率和提前显效时间、减少降血压药物的数量,同时显著降低高血压患者的焦虑、抑郁和躯体化症状的水平。

Objective To explore the adjunctive effect of the anti-anxiety-depression drug flupentixol 0. 5 mg＋ melitracen 10 mg/d（Deanxit） on essential hypertension in menopause women. Methods Eighty essential hypertension patients in menopause women were randomly divided into two groups：experimental group （n = 40, routine antihypertensive drugs and Deanxit） and control group （n = 40, routine antihypertensive drugs and VitB6）. All patients underwent SCL-90 baseline assessment at the eighth week after treatment. The reduction of mean blood pressure, effective rate, the number of the antihypertensive drugs needed to achieve goal BP and the scores of SCL-90 were compared. Results （1） Compared with control groups, the reduction of mean blood pressure E（130. 6±13.5）/（80.7±10. 3） vs control： （150.0±14.5）/（94.5±12.6）mm Hg, P〈0.01], the effective rate were much greater（86.8% vs control ：59.4 %, P〈0.01） from the 2nd week of treatment until the end of study. （2）From the fifth week of treatment, more antihypertensive drugs were used in control group than that in the experimental groups（3.5±0.6 vs 1.8±0.6, P〈0.01）. （3） In experiment group, the scores of SCL-90 ineluding anxiety and depression and somatic symptom were significantly lower than that before treatment while little changes in the scores of SCL-90 factors found in the control group. Conclusion Significanty synergic effects of the anti-anxiety-depression and antihypertensive drugs on essential hypertension in menopause women were found. The anti-anxiety-depression treatment increases the effective rate of treatment, decrease the number of antihypertensive drugs, and the degree of anxiety and depression and somatic symptoms in menopause women.