中性粒细胞弹性蛋白酶和elafin蛋白与皮肤肿瘤
被引量:1
Skin Tumors and Neutrophil Elastase with Elafin
摘要
皮肤肿瘤组织中浸润的中性粒细胞及瘤细胞可以合成、分泌中性粒细胞弹性蛋白酶及其抑制剂elafin蛋白,共同参与了皮肤肿瘤的分化。中性粒细胞弹性蛋白酶能够促进瘤细胞增殖、扩散及转移,中性粒细胞弹性蛋白酶/ela-fin失衡可能参与了皮肤肿瘤的生长调控。中性粒细胞弹性蛋白酶和elafin在皮肤肿瘤中的作用机制值得深入研究。
出处
《中国皮肤性病学杂志》
CAS
北大核心
2007年第2期123-124,共2页
The Chinese Journal of Dermatovenereology
参考文献20
-
1Starcher B,O' Neal P,Granstein RD,et al.Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice[J].J Invest Dermatol,1996,107 (2):159-163.
-
2Foekens JA,Ries C,Look MP,et al.The Prognostic Value of Polymorphonuclear Leukocyte Elastase in Patients with Primary Breast Cancer[J].Cancer Res,2003,63(2):337 -341.
-
3Achilles K,Bednarski PJ.Quantification of elastase-like activity in 13 human cancer cell lines and in an immortalized human epithelial cell line by RP-HPLC[J].Biol Chem,2003,384(5):817-824.
-
4Yamaguchi K,Shimada S,Tashima S,et al.A potentially novel peptidase,resembling but distinct from neutrophil elastase,produced by carcinoma cells[J].Oncol Rep,2000,7(5):1017 -1021.
-
5Westin U,Nystrom M,Ljungcrantz I,et al.The presence of elafin,SLPI,IL1-RA and STNFalpha RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation[J].Mediators Inflamm,2002,11(1):7 -12.
-
6Alkemade HA,Molhuizen HO,Vlijmen-Willems IM van,et al.Differential expression of SKALP/Elafin in human epidermal tumors[J].Am.J.Pathol,1993,143 (6):1679 -1687.
-
7Yoshida N,Egami H,Yamashita J,et al.Immunohistochemical expression of SKALP/elafin.in squamous cell carcinoma of human lung[J].Oncol Rep,2002,9 (3):495 -501.
-
8Liu HJ,Moroi S,Yasumoto S,et al.Expression of elafin in extramammary Paget's disease[J].Br J Dermatol,2005,152(3):578-579.
-
9Rogalski C,Meyer-Hoffert U,Proksch E,et al.Human leukocyte elastase induces keratinocyte proliferation in vitro and in vivo[J].J Invest Dermatol,2002,118 (1):49-54.
-
10Meyer-Hoffert U,Wingertszahn J,Wiedow O.Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation[J].J Invest Dermatol,2004,123 (2):338-345.
同被引文献26
-
1Zhifu S, Ping Y. Role of imbalance between neutrophil elastase and 1-antitrypsin in cancer development and progression[ J ]. Lancet Oncol, 2004, 5 ( 3 ) : 182-190.
-
2Shapiro SD. Neutrophil elastase path clearer, pathogen killer, or just pathologic [ J ]. Am J Respir Cell Mol Biol, 2002,26 ( 3 ) : 266 -268.
-
3Campbell E J, Senior RM, Welgus HG. Extracellular matrix injury during lung inflammation[ J]. Chest, 1987, 92( 1 ) :161-167.
-
4Lungarella G, Cavarra E, Lucattelli M, et al. The dual role of neutrophil elastase in tung destruction and repair [ J ]. Int J Biochem Cell Biol, 2008, 40(6-7):1287-1296.
-
5Depuydt B, Van Loo G, Vandenabeele P, et al. Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors[ J ]. J Cell Sci,2005, 118 (3) :497-504.
-
6Wada Y, Yoshida K, Tsutani Y, et al. Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines [ J]. Oncol Rep, 2007, 17 (1) :161-167.
-
7Chen G, Goeddel DV. TNF-RI signaling:a beautiful pathway[ J]. Science, 2002, 296(5573 ) : 1634-1635.
-
8Gasparini C, Menegazzi R, Patriarca P, et al. Evidence that elastase is the TNF-R75 shedding enzyme in resting human polymorphonuclear leukoeytes [ J ]. FEBS Lett, 2003, 553 (3) :360-364.
-
9Starcher B, O' Neal P, Granstein RD, et al. Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice[J]. J Invest Dermatol, 1996, 107(2) :159-163.
-
10Taniguchi K, Yang P, Jett J, et al. Polymorphisms in the promoter region of lhe neutrophil elastase gene are associated with lung cancer development [ J ]. Clin Cancer Res, 2002, 8 (4) : 1115-1120
二级引证文献2
-
1田宁,张培彤.中性粒细胞增多与恶性肿瘤进展及转移关系的研究[J].中国肿瘤,2010,19(7):470-476. 被引量:6
-
2蒋开玲,马鹏鹏,阳小群,钟梁,王慧,朱新瑜,刘北忠.中性粒细胞弹性蛋白酶的过表达促进K562细胞增殖并抑制其凋亡[J].细胞与分子免疫学杂志,2015,31(2):159-162. 被引量:3
-
1皮肤肿瘤[J].中国医学文摘(皮肤科学),2008,25(2):122-128.
-
2徐海声,宁四清.中性粒细胞弹性蛋白酶与结肠癌肝、肺转移的关系[J].实用癌症杂志,2016,31(9):1420-1422. 被引量:2
-
3马铁军,周其全.中性粒细胞弹性蛋白酶与肿瘤的发生发展[J].国际病理科学与临床杂志,2008,28(5):399-402. 被引量:2
-
4夏天放,徐果.中性粒细胞弹性蛋白酶对HepG2细胞增殖的影响及其机制的研究[J].胃肠病学和肝病学杂志,2016,25(9):1009-1013. 被引量:2
-
5廖泽飞,林勇龙,马良赟.乌司他丁对食管癌术后炎症的治疗效果[J].贵阳医学院学报,2016,41(9):1108-1110. 被引量:1
-
6张超,孙治君.乌司他丁对乳腺癌细胞迁移、黏附、侵袭能力的影响及机制[J].重庆医学,2012,41(26):2685-2688. 被引量:1
-
7朱丹,王翀,刘北忠,钟梁,王春光,吴燕.酵母双杂交技术筛选并回转验证在胞内与PML-C结构域相互作用的蛋白[J].医学分子生物学杂志,2010,7(3):242-246. 被引量:8
-
8王慧,刘北忠,阳小群,朱新瑜,马鹏鹏,蒋开玲,钟梁.急性早幼粒细胞白血病患者血肿瘤细胞NLS-RARα蛋白的表达与定位[J].第二军医大学学报,2015,36(3):241-247. 被引量:2
-
9王翀,钟梁,王东生,刘北忠,廖飞,郝坡,刘畅,金丹婷,王春光.NLS-RARα蛋白相互作用蛋白的筛选与验证(英文)[J].生物化学与生物物理进展,2009,36(4):500-505. 被引量:6