精神病医院门诊苯二氮类药物使用情况分析

ANALYSIS OF THE USE OF BENZODIAZEPINES IN A MENTAL HEALTH HOSPITAL

目的:了解我院门诊苯二氮类药物(BDZ)的使用情况。方法:随机抽取华中科技大学同济医学院附属精神病医院2005年1月-12月1a中门诊西药处方6472张,对其中1824张含有苯二氮类药物的处方进行分析。并用限定日剂量(DDD)和药物利用指数(DUI)为指标分析其使用情况。结果:含有苯二氮类药物的处方占总处方的28.18%,出现率最高的为氯硝西泮,占43.04%;依次为阿普唑仑25.0%,地西泮16.67%,艾司唑仑9.70%,硝西泮5.04%,劳拉西泮0.55%。其中地西泮、硝西泮和劳拉西泮的DUI均略小于1;阿普唑仑、氯硝西泮和艾司唑仑的DUI略大于1。处方中用药时间超过4周的处方高达60.42%,其中超过12周的处方为8.33%,最高处方日数为150d。结论:该院医师对苯二氮类药品的滥用倾向不明显,但对苯二氮类药物使用存在着日处方数较高等方面问题。

Objective： To understand the use of benzodiazepines （BDZ） in a mental health hospital. Methods： An analysis of 6472 prescriptions which were randomly selected from the prescriptions prescribed from January 2005 to December in the Psychiatric Hospital of Tongji Medical College was conducted with daily defined dose （DDD） and drug utilization index （DUI）. Results： Among 6472 prescriptions,1824（28. 18% ） included BDZ. They were clonazepam （43. 04% ）, alprazolam （25. 0% ）, diazepam （ 16. 67% ） ,estazolam （9. 70% ）, nitrazepam （5.04%） and lorazepam （0. 55% ）. The DUI of diazepam, nitrazepam and lorazepam was a little less than 1, while the DUI of clonazepam, alprazolam and estazolam was more than 1. The prescriptions lasted over four weeks and more than twelve weeks accounted for 60. 42% and 8.33% ,respectively. The longest duration was 150 days. Conclusion： It is not obvious that doctors in this hospital abuse BDZ,but there exist some problems.