摘要
目的评价中药导痰汤合并小剂量利培酮和单独使用利培酮治疗痰湿内阻型慢性精神分裂症的临床疗效。方法对住院的65例患者随机分为两组,治疗组(34例)用利培酮每日(3.16±0.73)mg加中药导痰汤加减(常规剂量),每日1剂煎服;对照组(31例)单用利培酮每日(5.11±1.27)mg;疗程均为8周。以阳性与阴性症状量表(PANSS)作为主要疗效评价指标,以治疗时出现的症状量表(TESS)评定不良反应。结果两组总体疗效比较差异无显著性,治疗组阴性症状、激活性和一般精神病理方面的改善较对照组明显(P<0.05),且治疗组药物不良反应出现频率较对照组低,而且轻微。结论中药合并小剂量抗精神病药物不失为治疗慢性精神分裂症的一种有效方法,且减少不良反应。
Objective To evaluate the clinical efficacy of modified Daotan Decoction (DD) combining low dosage of risperidone in treating chronic schizophrenia patients of phlegm-dampness blockage type, and compare with patients treated with risperidone alone. Methods Sixty-five inpatients were randomly assigned to two groups, the treatment group (34 cases) treated with DD (with conventional dosage) one dose per day and risperidone 3.16 ± 0.73 mg/d, and the control group (31 cases) treated with risperidone 5.11 ± 1.27 mg/d alone, the course for both groups was 8 weeks. The effect was evaluated with positive and negative syndrome scale (PANSS), and the adverse reaction was assessed with treatment emergent symptom scale (TESS). Results There was no significant difference in the overall efficacy between the two groups, but the improvement of the negative symptoms, illness provocation and general psychopathologic condition was significantly better in the treatment group than that in the control group respectively (P 〈 0.05). Moreover, the adverse reaction was milder and less in the former than that in the latter. Conclusion The treatment of DD combined with low dosage of risperidone is effective on chronic schizophrenia and shows
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2007年第3期208-210,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
中药导痰汤加减
利培酮
慢性精神分裂症
阳性与阴性症状量表
不良反应
modified Daotan Decoction
risperidone
chronic schizophrenia
positive and negative syndrome scale
adverse reaction