“以方测证”方法应用的反思

Rethinking on Application of“Syndrome Differentiation through Formula Effect Assessment”

通过总结“以方测证”方法的应用概况,指出在应用过程中主要存在实验对照设立不合理、药效学指标的选择过于简单、“药病对应”的研究受到忽视等问题。从而提出应用“以方测证”方法进行研究,必须设立对照;病证结合是“以方测证”的关键点;方剂功效的界定是“以方测证”的前提等相应的研究思路和对策。

By summarizing the state of application of ＂syndrome differentiation through formula effect assessment＂, it was pointed out that several problems exist in this kind of study, mainly the irrational setting of experimental control group, over simplified pharmacodynamic indexes, and negligence of study on ＂correspondence between drug and disease＂, etc. The authors proposed accordingly the thinking methods and strategy in the study on ＂syndrome differentiation through formula effect assessment＂ should he setting control properly, taken ＂correspondence between disease and syndrome＂ as the key point, and to define clearly the criteria for evaluating the efficacy of formula as the premise.