药物代谢性别差异及与核受体的关系

Gender difference of drug metabolism and its mechanism

药物代谢存在着性别差异,性别差异如何影响药物代谢?机制如何?目前国内外均没有完整系统的结论。性别差异主要在于性激素的不同,雌二醇是雌激素的主要活性成份,阐明雌二醇对肝细胞药物代谢相关基因的影响,可以解释性别差异导致药物代谢差别的原因,从而能提高妇女及肝病患者的用药安全性。该文重点阐述了雌激素对药物代谢酶的影响以及与核受体的联系。

The extent to which sex influence CYP activity remains unclear in humans. Estrogen have widespread biologic actions especially estradiol , it can be used in ERT and Oral contraceptives. What is the effect of estrogen on drug metabolism and transport？ If estrogen can regulate the genes of drug metabolism and transport,what is the mechanism.