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失巢凋亡在As斑块破裂中的作用及机制 被引量：9

Anoikis in rupture of atherosclerotic plaque
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摘要 失巢凋亡是一种特殊形式的细胞程序性死亡,不仅参与了机体组织自身平衡的调节,而且还参与了许多病理过程的发生,如动脉粥样硬化(atherosclerosis,As)、急性冠脉综合征、心力衰竭、动脉瘤和肿瘤等。该文综述了失巢凋亡在As斑块不稳定性和破裂中的作用及机制。 Anoikis is a special programmed cell death and plays important roles in both physiological regulation and pathogenesis of many diseases, including atherosclerosis, acute coronary syndrome, cardiac failure, aneurysm and tumors. This review focuses on the association of the anoikis with instability and rupture of atherosclerotic plaque.
作者 刘娜 刘俊田
机构地区 西安交通大学医学院药理学系
出处 《中国药理学通报》 CAS CSCD 北大核心 2007年第3期298-301,共4页 Chinese Pharmacological Bulletin
关键词 失巢凋亡 动脉粥样硬化斑块 血管平滑肌细胞 细胞外基质 细胞外周基质 基质金属蛋白酶 anoikis atherosclerotic plaque vascular smooth muscle cell extracellular matrix pericellular matrix matrix metalloproteinase
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献18

  • 1Kataoka H,Kume N,Miyamoto S,et al.Oxidized LDL modulates Bax/Bcl-2 through the lectin-like ox-LDL receptor-1 in vascular smooth muscle cells[J].Arterioscler Thromb Vasc Biol,2001,21:955-60.
  • 2Sukhanov S,Hua S Y,Delafontaine P.Global analysis of differentially expressed genes in oxidized LDL-treated human aortic smooth muscle cells[J].Biochem Biophys Res Commun,2003,306:443-9.
  • 3金炜,董维平,杨红,何奔,孙宝贵.转化生长因子β_1在动脉粥样硬化形成中的作用及机制研究[J].中国药理学通报,2003,19(6):650-653. 被引量：16
  • 4Patel V A,Zhang Q J,Siddle K,et al.Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling[J].Circ Res,2001,88:895-902.
  • 5Dimmeler S,Zeiher A M.Reactive oxygen species and vascular cell apoptosis in response to angiotensin Ⅱ and proatherosclerotic factors[J].Regul Pept,2000,90:19-25.
  • 6Geng Y J,Libby P.Progression of atheroma:a struggle between death and procreation[J].Arterioscler Thromb Vasc Biol,2002,22:1370-80.
  • 7Michel J P.Anoikis in the cardiovascular system:known and unknown extracellular mediators[J].Arterioscler Thromb Vasc Biol,2003,23:2146-54.
  • 8Heeneman S,Cleutjens J P,Faber B C,et al.The dynamic extracellular matrix:intervention strategies during heart failure and atherosclerosis[J].J Pathol,2003,200:516-25.
  • 9Lindstedt K A,Leskinen M J,Kovanen P T.Proteolysis of the pericellular matrix:a novel element determining cell survival and death in the pathogenesis of plaque erosion and rupture[J].Arterioscler Thromb Vasc Biol,2004,24:1350-8.
  • 10Ross R S,Borg T K.Integrins and the myocardium[J].Circ Res,2001,88:1112-9.

二级参考文献25

  • 1王旭开,杨成明,刘光耀,谯怡然.复合胶元酶法分离人血管平滑肌细胞的新方法[J].第三军医大学学报,1993,15(4):357-360. 被引量：13
  • 2Ross R.Atherosclerosis--An inflammatory disease.N Engl J Med,1999;340(2):115～26
  • 3Pasceri V,Willerson JT,Yeh ETH.Direct proinflammatory effect of C-reative protein on human endothelial cells.Circulation,2000;102(18):2165～8
  • 4Pasceri V,chang J,Willerson JT et al.Modulation of C-reative protein-mediated moncyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs.Circulation,2001 ;103(21):2531～4
  • 5Edward TH,James T,Willerson JT.Coming of age of Creative protein.Circulation,2003;107(3):370～2
  • 6Subodh V,Shu-hong L,Mitesh V et al.Endothelin antagonism and interleckin-6 autenuate the proatherogenic effect of Creative protein.Circulation,2002 ; 105(16):60～6
  • 7Schonbeck U,Libby P.CD40 signaling and plaque instability.Circ Res,2001 ;89(12):1092～3
  • 8Lutgens E,Daemen MJ.CD40-CD40L interactions in atherosclerosis.Trends Cardiovasc Med,2002 ;12(1):27～32
  • 9Schonbeck U,Gerdes N,Varo N et al.Oxidixed low-density lipoprotein augments and 3-hydroxy-3-methlglutary coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells.Circulation,2002;106(23):2888～939
  • 10Bruemmer D,Riggers U,Holzmeiser J et al.Expression of CD40 in vascular smooth muscle cells and mcrophages is associated with early development of human atherosclerosis lesions.Am J Cardiol,2001 ;87(1):21～7

共引文献50

同被引文献116

引证文献9

二级引证文献176

中国药理学通报
2007年 第3期

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