(S)-(+)-2-(2-萘)-2-N-甲基氨乙醇的合成与表征

Synthesis and characterization of (S)-(+)-2-(2-naphthyl)-2-(N-methyl)aminoethanol

以β-萘乙烯为原料，通过烯烃的Sharpless不对称双羟化、环化、开环、催化氢化、甲酰化、还原等6步反应，生成标题化合物，总产率以β-萘乙烯计为39．7％，e．e．值高达97％-99％。对产物进行了质谱、红外光谱、^1HNMR和^13CNMR表征。

（ S ）-（ ＋ ）-2-（ 2-Naphthyl ）-2-（ N-methyl ） aminoethanol was synthesized from （ R ）-1-naphthalen-2- ylethane-1,2-diol produced by the Sharpless asymmetric dihydroxylation, eyelization of diols, azide opening of epoxides, catalytic hydrogenation of the resulting azido alcohols, formylation of the chiral β-amino alcohol and reduction of the corresponding formamide. The six-step procedure starting from 2-vinylnaphthalene resulted in a total yield of 39.7% with the e. e.values reaching up to 97% - 99%. Its structure was characterized by IR, ^1HNMR, ^13CNMR and MS.