聚(癸二酸-聚乙二醇)酸酐的合成研究

Synthesis of PEG-polyanhydride

采用熔融缩聚法合成了标题化合物。考查了反应温度、反应时间、真空度及物料配比等因素对聚合物相对分子质量的影响。实验结果表明:在反应温度为185℃,反应时间为90 min,真空度为25 Pa,两种预聚物w(产物2)∶w(产物3)=80∶20条件下,聚合物的相对分子质量达9 000以上。通过FT-IR及1HNMR对合成产物进行了表征。

PEG-polyanhydride was synthesized via melt polycondensation. The effect of vacuum, reaction temperature, reaction time and mass ratio of the raw materials on the polymer molecular weight was studied. The experimental results showed that the optimum conditions were as follows：the reaction temperature was 185 ℃ , the reaction time was 90 min, the vacuum was 25 Pa and the mass ratio of product 2 to product 3 was 80： 20. Under these conditions, the molecular weight of the product could be above 9 000. The polymer was characterized by means of FT-IR and ^1HNMR.