期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

多肽、蛋白质药物缓释微球研究进展 被引量：2

Research development on Polypeptide-Protein microspheres
下载PDF
导出
摘要 目的介绍多肽、蛋白质缓释微球的研究情况。方法通过查阅国内外文献,综述多肽、蛋白质微球的制备技术,影响微球质量和体外释药的因素以及药物的稳定性问题。结果与结论多肽、蛋白质药物缓释微球在药学领域有着广阔的发展前景。 Objective Reviewing the recent development and progress on polypeptide-protein microspheres. Method According to a large quantity of documents concerned, the preparation ways of polypeptide-protein microspheres are reviewed. The influence factors of the characters of microspheres and the release of drug are discussed. Results and Conclusions Polypeptide-protein microspheres have broad prospects in the pharmaceutical filed.
作者 张海龙 林建强
机构地区 山东教育学院生物科学与技术系 山东大学微生物技术国家重点实验室
出处 《现代食品与药品杂志》 2007年第1期26-29,共4页 JOurnal of Modern Food and Pharmaceuticals
关键词 多肽 蛋白质 缓释 微球 polypeptide protein sustained release microsphere
分类号 R94 [医药卫生—药剂学]
  • 相关文献

参考文献22

  • 1钟延强,吴诚,刘善奎,尹东锋.蛋白质药物聚乳酸/羟基乙酸共聚物微球处方工艺设计中稳定化方法的研究进展[J].中国药学杂志,2005,40(3):165-168. 被引量：5
  • 2Fang-jing W,Chihwa W.Sustained release of etanidazole from spray dried microspheres prepared by non-halogenated solvents[J].J Controlled Release,2002,81(4):263-280.
  • 3Ywujang F,Shinshing S,Fuhu S.Development of biodegradable PLGA microspheres for the controlled release of 5-FU by the spray drying method[J].Colloids Surfaces,2002,6:269-279.
  • 4Maryellen S,David E,Paula W.Effect of protein molecular weight on release from micron-sized PLGA microspheres[J].J Controlled Release,2001,76(6):297-311.
  • 5Fwulong M,Shinshing S,Yimei L.Chintin/PLGA blend microspheres as a biodegradable drug delivery system:a new delivery system for protein[J].Biomaterials,2003,(11):5023-5036.
  • 6Soppimath KS,Aminabhavi TM,Kulkani AR.Biodegradable polymeric nanoparticles as drug delivery devices[J].J Control Release,2001,70(9):1-20.
  • 7Carrascosa C,Espejo L,Torrado S,et al.Effect of gamma-sterilization process on PLGA microspheres loaded with insulin-like growth factor-I(IGF-I)[J].J Biomater Appl,2003,18(2):95-108.
  • 8Mohr D,Wolf M,Kissel T.Gamma irradiation for terminal sterilization of 17 β-estradiol loaded poly-(D,L-latide-co-glycolide) micropartides[J].J Control Release,1999,61:203-217.
  • 9Montanari L,Cilurzo F,Valvo L.Gamma irradiation effects on stability of poly (lactide-co-glycolde) microspheres containing donazepam[J].J Control Release,2001,75:317-330.
  • 10杨帆,韩芸,冯穗生,金描真,张志宏.环丙沙星聚乳酸微球体外释药性能的研究[J].广东药学院学报,2002,18(4):261-262. 被引量：2

二级参考文献38

  • 1Lai MC,Topp EM. Solid-state chemical stability of proteins and peptides[J]. J Pharm Sci,1999,88(5) :89.
  • 2Diwan M,Park TG. Stabilization of recombinant interferon-a by pegylation for encapsulation in PLGA microspheres[J],Int J Pharm,2003,252(1～2):11.
  • 3Park TG,Lee HY,Nam YS. A new preparation method for protein loaded poly(D,L-lactic-co-glycolic acid)microspheres and protein release mechanism study[J]. J Controlled Release,1998,55(2～3):181.
  • 4Nam YS,Park TH. Protein loaded biodegradable microspheres based on PLGA-protein bioconjugates[J]. J Microencapsul,1999,16(5):625.
  • 5Johansen P,Corradin G,Merkle HP,et al. Release of tetanus toxoid from adjuvants and PLGA microspheres:now experimental set-up and surface adsorption fool the pattern[J]. J Controlled Release,1998,56(1～3):09.
  • 6Wang W. Instability,stabilization,and formulation of liquid protein pharmaceuticals[J]. Int J Pharm,1999,185(2):129.
  • 7Sebeka HK,Srarkuviene B,TrepSiene OV,et al. Comparative effects of stabilizing additives on the rates of heat inactivation of recombinant human interfaron α-2b in solution[J]. Antiviral Res,2001,50(2):17.
  • 8Fu K,Klibanov AM,Langer R. Protein stability in controlled-release systems[J]. Nature Biotechnol,2000,18(1):4.
  • 9Cleland JL,Jones AJS. Stable formulations of recombinant human growth hormone and interferon-γ for microencapsulation in biodegradable microspheres[J]. Pharm Res,1996,13(10):464.
  • 10Cleland JL. Solvent evaporation processes for the production of controlled release biodegradable microsphere for therapeutics and vaccines[J]. Biotechnol Prog, 1998, 14( 1 ) : 102.

共引文献25

同被引文献78

  • 1冷迪,彭博,王毅飞,刘津爱,王明新,王东凯.醋酸奥曲肽微球的制备及工艺优化[J].中国药剂学杂志（网络版）,2010(1):1-8. 被引量：2
  • 2王襄平,梅兴国.多肽及蛋白类药物微球包封率和释放的研究进展[J].国外医学（药学分册）,2006,33(3):219-223. 被引量：11
  • 3李振环,秦张峰,王建国.碳酸二甲酯与苯酚酯交换催化合成碳酸二苯酯[J].石油化工,2006,35(6):528-532. 被引量：20
  • 4毕殿洲 主编.药剂学[M].北京：人民卫生出版社,2002.321.
  • 5陈庆华,瞿文.多肽、蛋白质药物的微球给药系统研究进展[J].国外医学（药学分册）,1997,24(3):129-133. 被引量：20
  • 6Mirshahidi S, Kramer V G, Whitney J B, et al. Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival [ J ]. Vaccine,2009,27 ( 12 ) : 1825 - 1833.
  • 7Sehwarz J C, Klang V, Karall S, et al. Optimisation of Multiple W/O/W Nanoemulsions for Dermal Delivery of Acyclovirs [ J ]. Int J Pharm, 2012,435( 1 ) :69 -75.
  • 8Gao Z H,Tang Y,Chen J Q,et al. A novel DPP- IV -resistant analog of glucagons - like Peptide - | ( GLP - 1 ) : KGLP - 1 ',:done or in comb- inection weth long- acting PLGA microspheres [ J ]. Peptides, 2009,30 (10) : 1874 - 1877.
  • 9Rawat A, Burgess D J. USP apparatus 4 method fir in vitro release tes- ting of protein loaded microspheres [ J ]. Int J Pham1,2011,409 (1 -2 ) : 178 - 184.
  • 10Guo Ai,Xing- Guo Mei. An accelerated method to evaluate thymopen- tin release from microspheres in vitro [ J ]. Journal of Chinese Pharmaceu- tical Sciences, 2008,17:41 - 45.

引证文献2

二级引证文献7

现代食品与药品杂志
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部