78例茶碱血药浓度监测分析

Plasma Concentration Monitoring and Analysis of Theophylline in 78 cases

目的分析茶碱血药浓度与疗效和不良反应发生的关系,并简要分析茶碱血药浓度的影响因素。方法采用荧光偏振免疫法测定血清中茶碱的浓度,从血药浓度与疗效、不良反应发生以及合并用药几个方面进行分析、归纳。结果76.84%病例的茶碱血药浓度低于10μg/m l,有效率为79.5%,不良反应发生率为33.3%;18.2%病例的茶碱血药浓度在10-20μg/m l,有效率为77.8%,不良反应发生率为75%。结论较低浓度的茶碱配合其他药物治疗对呼吸道疾病会得到很好的疗效,且副作用小。

Objective To analyze the relationship between the plasma concentration, and the effect and adverse drug reaction of theophylline, and the influencing factors of theophylline plasma concentration. Method The plasma concentration of theophylline was assayed by fluorescence polarization immunoassay, then the data was analyzed from the relationship among the plasma concentration, the effect, the adverse drug reaction. Results Of the 76.84% cases, the plasma concentration of theophylline was under 10 μg/ml with effective rate 79.5% and untoward reaction rate 33.3%. of the 18.2% cases, the plasma concentration of theophylline was in the range of 10 - 20 μg/ml, with effective rate 77.8% and adverse drug reaction rate 75%. Cone.lnsion Lower plasma concentration of theophylline combining with the other drugs has better effectiveness on respiratory disease.