摘要
A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2',6'-trihydroxy-3'″, 8-di (γ,γ-dimethyl-allyl)-2'″, 2'″-dimethylpyrano-[5'″,6'″: 6,7]-2'″″,4'″″-cyclohexadiene-1 '″″-one-[2'″″,3'″″: 3',4']-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.
A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2',6'-trihydroxy-3'″, 8-di (γ,γ-dimethyl-allyl)-2'″, 2'″-dimethylpyrano-[5'″,6'″: 6,7]-2'″″,4'″″-cyclohexadiene-1 '″″-one-[2'″″,3'″″: 3',4']-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.