肝脏FDG代谢模型的参数估计

Kinetic model parameter estimates of liver FDG metabolism

利用房室模型进行肝脏[18F]氟代脱氧葡萄糖([18F]2-fluoro-2-deoxy-D-glucose,FDG)代谢的动力学研究是进行人体功能信息的建模和研究肝脏葡萄糖代谢率的重要手段。动力学研究需要得到血液中的示踪剂浓度随时间变化曲线,将其作为模型的输入,估计出肝脏FDG代谢模型的动力学参数。然而,肝脏存在肝动脉输入和肝门静脉输入。研究分别采用动脉和门静脉的双输入方式和动脉的单输入方式作为血液输入曲线,用这两个输入函数分别进行了肝脏FDG代谢的动力学研究,比较了用两种方法所得到的结果。结果显示,在人体肝脏的FDG代谢研究中,用两种输入曲线得到的结果存在明显的不同,并且用双输入曲线得到的结果更加准确。

Liver kinetic studies of [^18F]2-fluoro-2-deoxy D-glucose （FDG） metabolism are important tools for functional information modeling and hepatic glucose metabolic rate estimates. Kinetic parameter estimates require the arterial blood time-activity curve and the tissue time-activity curve as input and output functions. For liver studies, however, the conventional arterial-input may not be consistent with the real model input because the liver has a dual blood supply from the hepatic artery and the portal vein to the liver. This study compares model parameter estimates using a dual-input function with results using an arterial input function. The results show that the two methods provide different parameter estimates with the dual input function leading to more accurate parameter estimates.