参附注射液对重症急性胰腺炎患者血浆内皮素、一氧化氮浓度的影响

The Effect of Shenfu Injection on Plasma Endothelin and Nitric Oxide Levels of Patients with Severe Acute Pancreatitis

目的观察参附注射液(SFI)对重症急性胰腺炎(SAP)患者血浆内皮素(ET)、一氧化氮(NO)的影响及对SAP的治疗作用,并探讨其机制。方法将73例SAP患者随机分为两组,治疗组在西医综合治疗基础上加用SFI静滴,对照组仅予西医综合治疗,另选20名健康体检者作为正常对照组;检测两组治疗前及治疗后10d血浆ET、NO、ET/NO及血、尿淀粉酶。结果SAP组较正常对照组ET、NO、ET/NO及血、尿淀粉酶显著增高;治疗后治疗组较对照组各值明显降低,腹痛缓解及住院时间明显缩短。结论SFI能调节SAP时ET和NO的平衡,对SAP有良好的治疗作用。

Objective： To investigate the effect of Shenfu lnjection（SFI, 参附注射液） on plasma endothelin （ET） and nitric oxide（NO） levels in patients with severe acute pancreatitis（SAP）, and the mechanisms. Methods： 73 patients with SAP were randomly divided into 2 groups. Those in treated group were treated by general medicing and SFI, while in the control group were generally treated. 20 healthy persons served as normal control group. Plasma ET, NO, amylase（AMY） and uric AMY were determined before and after therapy 10 days. Results： Compared to healthy subjects, the levels of plasma ET, NO, ET/NO, AMY and uric AMY in patients with SAP increased sig- nificantly. All determined indexes, catabatic time of bellyache and time of hospitalization in treated group decreased significantly compared to control group. Conclusion： SFI can modulate the balance of ET and No, and has favorable treatment effect on patients with SAP.