青年人结直肠癌临床病理特征分析

Analysis of clinical pathological characteristics of colorectal cancer in young men

目的:探讨青年人结直肠癌的临床病理特征。方法:回顾性分析结直肠癌患者342例,其中年龄≤40岁青年组33例,以及随机抽取其中年龄≥60岁的老年患者33例,分析两组的临床特征。结果:青年组肿瘤部位以直肠多见,误诊率(54.55%)明显高于老年组(30.3%);两组的癌性家族史及病理组织学分布均有显著性差异。结论:青年人结直肠癌发病部位以直肠最常见,有癌性家族史者易发生,误诊率较老年人高,诊断时多为中晚期,肿瘤分化较差。

Objective To study the clinical pathological characteristics of colorectal cancer in young patients. Methods We performed a retrospective analysis on 342 cases： young （aged under 40） and elderly （aged over 60）, who were made definite diagnosis with colorectal cancer during a 10-year period（1995-2005）.Comparing clinical pathological representation of two groups. Results 54.55 percent were misdiagnosed in young group which were significantly higher than older patients（30.3 percent）;The proportion of family cancer history young patients significantly incersased （17.27 percent in young group vs. 6.06 percent in old group）;The proportion of poorly differentiated tumors more significantly increased in young ,group than that in the elderly group （45.45 percent vs 18.18 percent）. Conclusion Incidence rates for colorectal cancer in young patients are about 9.65 percent.There are cancer family history more vulnerable to suffer from colorectal cancer in young patients.Young colorectal cancer pa- tients present more often with worse tumor differentiation and later-stage disease than their older counterparts.