摘要
胰升糖素样肽-1（GLP-1）是一种肠促胰岛素，它通过复杂的机制降低餐后血糖。β细胞凋亡在胰腺的正常生理、糖尿病的发病机理及胰岛移植存活方面都起着重要的作用。新近的研究发现GLP-1不但能刺激β细胞增殖和分化，而且还可抑制凋亡从而起到保护β细胞的作用。GLP-1受体激动剂或类似物及二肽基肽酶Ⅳ抑制剂在治疗糖尿病和改善胰岛移植方面均有良好的应用前景。研究GLP-1对胰岛β细胞的保护作用及其机制，为开发用于治疗糖尿病及胰岛移植的新药提供了理论依据。
Glucagon-like peptide-1 （GLP-1） is an intestine-derived insulinotropic hormone that stimulates glucose dependent insulin production and secretion from pancreatic β-cells and decreases postprandial blood glucose via some complicated mechanisms. Apoptosis plays an important role in the normal physiology of the pancreas, the pathogenesis of diabetes mellitus and the survival of islet transplantation. Recently, GLP-1 have been shovm to stimulate the growth and differentiation of pancreatic β-cells, as well as to exert cytoprotective, antiapoptotic effects on β-cells. Recent evidences indicate that GLP-1 and its novel analog or agonists act on receptors to prompt β-cells survival. And dipeptidyl peptidase Ⅳ inhibitor prolongs and enhances the activity of endogenous GLP-1. All of these actions are potentially beneficial for the treatment of diabetes mellitus and improvement in the outcome of islet transplantation, and that provided the new theories base on exploiting drugs of prevention and/or treatment of diabetes mellitus in the future.
出处
《国际内分泌代谢杂志》
2007年第2期98-100,共3页
International Journal of Endocrinology and Metabolism
