二氧化硅粉尘对接触工人的肾毒性研究

A study of nephrotoxicity in workers exposed to silica dust

通过测定二氧化硅粉尘接触工人和矽肺病人尿白蛋白（ａｌｂ）、β＿２－微球蛋白（β＿２－ＭＧ）和Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）排出量，来确定肾毒性与二氧化硅粉尘接触的关系。结果表明：接尘工人和矽肺病人尿ａｌｂ、β＿２－ＭＧ和ＮＡＧ排出量显著高于对照组，其排出量增加与接尘工人接尘时间有关，而与矽肺病人脱离接尘的时间无关。证实二氧化硅粉尘可导致接触者出现慢性、非可逆性肾毒性反应。

This study is to find out the relations between nephrotoxicity and exposure to silica dust by measuring urinary excretions of albumin (alb),β_2-2-microglobulin(β_2-MG)and N-acetyl-β-D-glu-cosaminidase(NAG)in the workers exposed to silica dust and silicotic patients.The results showed that the urinary excretions of alb,β_2 MG and NAG in the silica exposed workers and silicotic patients were significantly higher than those in controls.These increase did relate with the duration of exposure in sil-ica exposed workers but not relate with the duration of deexposure in silicotic patients,indicating that exposure to silica dust may lead to chronic irreversible nephrotoxicity in exposed workers.