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噬菌体表面展示技术及其在靶向载体构建中的应用

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摘要 目的介绍噬菌体表面展示技术及其在靶向载体构建中的应用。方法主要综述了近年来国内外的相关文献。结果采用噬菌体表面展示技术可以高通量筛选单链抗体等靶向分子,将其连接至携载药物或基因的非病毒及病毒载体可提高其靶向性及产生更好的治疗效果。结论噬菌体表面展示技术的发展和成熟将为构建具有高效、特异性的靶向载体提供条件。
作者 帅武平 高建青 陈海靓 梁文权
机构地区 浙江大学附属第一医院 浙江大学药物制剂研究所
出处 《中国药学杂志》 CAS CSCD 北大核心 2007年第4期246-249,共4页 Chinese Pharmaceutical Journal
基金 国家自然科学基金资助项目(30572270)
关键词 噬菌体表面展示 载体 靶向分子
分类号 R392.11 [医药卫生—免疫学]
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参考文献33

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中国药学杂志
2007年 第4期

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