阿魏酸钠微孔渗透泵片的体内药动学与生物利用度

Pharmacokinetics and Bioavailability of Sodium Ferulate Porosity Osmotic Pump Tablets in Beagle Dogs

目的研究阿魏酸钠微孔渗透泵片在Beagle犬体内的药动学。方法以阿魏酸钠普通片为对照,应用HPLC测定血药浓度。结果阿魏酸钠微孔渗透泵片和普通片的tm ax分别为(4.833±0.725)和(1.000±0)h,t1/2分别为(12.892±2.879)和(5.824±1.659)h,mρax分别为(2.227±0.583)和(12.942±1.568)mg.L-1。相对生物利用度为98.4%。结论阿魏酸钠微孔渗透泵片血药浓度平稳,可较长时间保持血药浓度。

OBJECTIVE To study the pharmacokinetics and bioavailability of Sodium Ferulate porosity osmotic pump tablets in beagle dogs. METHODS With sodium ferulate conventional tablets as reference, sodium ferulate content-ration was determined by HPLC. RESULTS Main pharmacokinetic parameters were as follows： tmax（4.833 ±0.725） and （1.000 ±0）h,t1/2（12.892 ± 2. 879 ）and （5. 824± 1. 659 ）h ,Pmax （2. 227 ± 0. 583 ） and （ 12. 942 ± 1. 568 ）mg · L ^-1, for sodium ferulate porosity osmotic pump tablets and reference tablets, respectively. Relative bioavailability was 98.4%. CONCLUSION Plasma concentrations of sodium ferulate porosity osmotic pump tablets are constant and effective plasma drug concent-ration is kept for a long time.