铬对低硒状态下心肌损伤的保护作用

THE PROTECTIVE EFFECT OF CHROMIUM ON RAT MYOCARDIAL LESIONS IN SELENIUM DEFICIENCY

用克山病病区低硒（Ｓｅ）粮加铬（Ｃｒ）加Ｓｅ喂养大鼠，观察Ｃｒ对低Ｓｅ状态下心肌损伤的保护作用，超微结构观察发现病区粮组大鼠心肌细胞膜有轻度损伤，核畸形，有切迹，多数线粒体凝聚变性，部分线粒体嵴破坏，甚至消失成空泡变。心肌纤维疏松、纵向和横向断裂、有部分溶解现象，Ｚ带扭曲变性，有的肌丝Ｚ带消失。病区粮加Ｃｒ组、加Ｓｅ组及加Ｃｒ加Ｓｅ组病变明显减轻。心电图及心肌细胞内玻璃微电极检查，病区粮组ＱＲＳ时限、Ｑ－Ｔ间期及动作电位时程ＡＰＤ_（５０）、ＡＰＤ_（９０）延长，其他各组无变化。证实Ｃｒ对低Ｓｅ状态下心肌损伤有保护作用，并能逆转ＱＲＳ时限、Ｑ－Ｔ间期及ＡＰＤ的改变。Ｃｒ的保护作用对于克山病防治具有重要意义。

Rats were fed with low Se grain(from Keshan disease endemic areas) supplemeted with Cr and Se to investigate the protective effect of Cr on myocardial lesions. Ultrastructure examination in group B (fed with grain from Keshan disease area) revealed the most mitochrondrial siege agglutin ation and degeneration (even vacuolar degeneration), parallel and transverse disruption and even lysis of myofibrils, and Z-band degeneration or disapperance. Such changes were very slightin group C,D and E (supplemented with Cr, Se and Cr + Se respectively). The electrophysiological examination showed Q-T interval, APD50 and APD90 were prolonged in group B, but no changes in C,D, E groups. So Cr might not only protect myocardium from lesions in Se deficient condition, but also reverse the electrophysiological change, It suggested that Cr might play a role in prevention and treatment of Keshan disease.