吸入一氧化氮治疗肺血栓栓塞症的临床研究进展

Research progress of inhaled nitric oxide in pulmonary thromboembolism

吸入一氧化氮可以降低肺血栓栓塞症患者的肺血管阻力，降低肺动脉高压，解除右心室后负荷；治疗肺血栓栓塞症患者血栓手术后或肺动脉内肺血栓动脉内膜切除术后所形成的肺水肿、再灌注肺损伤和持续肺动脉高压等并发症；改善患者肺通气／血流失调，解除支气管痉挛，改善氧分压；抑制患者血小板活性和聚集，延长出血时间；对心肌损害和心功能的保护作用。吸入一氧化氮对患者有一定的毒副作用，一氧化氮吸入装置的不完善也对一氧化氮吸入在临床上的应用有一定的影响。对这些知识的全面认识，将对临床吸入一氧化氮治疗肺血栓栓塞起到积极的作用。

Inhaled nitric oxide can reduced pulmonary vascular resistance（PVR）, reduce pulmonary artery pressure and reduced right ventricular afterload,improved right-heart function in patients with acute pulmonary thromboembolism; successful treatment reperfusion edema, ischemia-reperfusion injury and persistent pulmonary hypertension after pulmonary embolectomy and pulmonary thromboendarterectomy; better ventilation/perfusion（V/Q） matching,and improved arterial oxygenation;to prolong bleeding time and to inhibit platelet aggregation; protected myocardial damage and cardiac function in patients with acute pulmonary thromboembolism. The sild-effect of inhaled nitric oxide in treatment patients with acute pulmonary embolism and not perfect of inhaled nitric oxide systems all are main factor that cinical using is limited about inhalation nitric oxide treatment diseases, to know this all knowledge will play a positive role about inhaled nitric oxide treatment patients with acute pulmonary embolism in clinical.